| Tag |
Content |
| dbPAF ID |
dbPAF-0001542 |
| Uniprot Accession |
O43447; PPIH_HUMAN; A6NNE7;
|
| Genbank Protein ID |
NP_006338.1; XP_005270419.1; XP_011538810.1;
|
| Genbank Nucleotide ID |
NM_006347.3; XM_005270362.1; XM_011540508.1;
|
| Protein Name |
Peptidyl-prolyl cis-trans isomerase H |
| Protein Synonyms/Alias |
|
| Gene Name |
PPIH |
| Gene Synonyms/Alias |
CYP20;CYPH; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.Functional Description
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MAVANSSPVN PVVFFDVSIG GQEVGRMKIE LFADVVPKTA ENFRQFCTGE FRKDGVPIGY 60
KGSTFHRVIK DFMIQGGDFV NGDGTGVASI YRGPFADENF KLRHSAPGLL SMANSGPSTN 120
GCQFFITCSK CDWLDGKHVV FGKIIDGLLV MRKIENVPTG PNNKPKLPVV ISQCGEM
178Fasta Sequence
>O43447|PPIH|Homo sapiens(Human)
MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0413--Isomerase
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0697--Rotamase
KW-0747--Spliceosome
|
| Interpro |
IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
|
| PROSITE |
PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
|
| Pfam |
PF00160--Pro_isomerase
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0016607--C:nuclear speck
GO:0005681--C:spliceosomal complex
GO:0071001--C:U4/U6 snRNP
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0016018--F:cyclosporin A binding
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0000398--P:mRNA splicing, via spliceosome
GO:0045070--P:positive regulation of viral genome replication
GO:0006461--P:protein complex assembly
GO:0006457--P:protein folding
GO:0000413--P:protein peptidyl-prolyl isomerization
|
