dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001541
Uniprot Accession O43439; MTG8R_HUMAN; B2RAE6; F8W6D7; Q5TGE4; Q5TGE5; Q5TGE6; Q5TGE7; Q8IWF3; Q96B06; Q96L00; Q9H436; Q9UJP8; Q9UJP9; Q9UP24;
Genbank Protein ID NP_001028171.1; NP_001034798.1; NP_005084.1; XP_006723949.1; XP_011527403.1; XP_011527405.1; XP_011527406.1;
Genbank Nucleotide ID NM_001032999.2; NM_001039709.1; NM_005093.3; XM_006723886.1; XM_011529101.1; XM_011529103.1; XM_011529104.1;
Protein Name Protein CBFA2T2
Protein Synonyms/Alias ETO homologous on chromosome 20;MTG8-like protein;MTG8-related protein 1;Myeloid translocation-related protein 1;p85;
Gene Name CBFA2T2
Gene Synonyms/Alias EHT;MTGR1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
8MAKESGISLKEIQVLPhosphoSitePlus22135298
33RVPAMPGSPVEVKIQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated15302935; 16381945; 23193290; 19690332; 22115753; 18988627;
85PTLNGAPSPPQRFSNcurated26074081
117TCGARQLSKLKRFLTPhosphoSitePlus22135298
218LLNTSIASPADSSELcurated26074081
245PERREENSFDRDTIAcurated25627689
264AKRVCTISPAPRHSPdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19664994; 19664995; 21406692; 16381945; 23193290; 18988627;
323EVRDRHHSLGLNGGYPhosphoSitePlus22135298
330SLGLNGGYQDELVDHPhosphoSitePlus22135298
399ENTELRKTGTELVSRdbPTM 3.0;HPRD 9;PhosphoSitePlus19664995; 16381945; 23193290; 18988627; 22135298
409ELVSRQHSPGSADSLdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated21406692; 22115753; 16381945; 23193290; 19651622; 20068231;
412SRQHSPGSADSLSNDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated21406692; 22115753; 16381945; 23193290; 20068231; 18988627;
430EFNSRPGTGYVPVEFPhosphoSitePlus22135298
517CGRKASETCSGCNIAPhosphoSitePlus22135298
519RKASETCSGCNIARYPhosphoSitePlus22135298
551GQNLHGQSPHGQGRPdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 20873877; 22817900
577SADCSVPSPALDKTSdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19664994; 16381945; 23193290; 18988627; 22135298; 25627689;
583PSPALDKTSATTSRSdbPTM 3.019664995; 16381945; 23193290
586ALDKTSATTSRSSTPcurated19690332
587LDKTSATTSRSSTPAcurated19690332
Sequence
(Fasta)		MAKESGISLK EIQVLARQWK VGPEKRVPAM PGSPVEVKIQ SRSSPPTMPP LPPINPGGPR 60
PVSFTPTALS NGINHSPPTL NGAPSPPQRF SNGPASSTSS ALTNQQLPAT CGARQLSKLK 120
RFLTTLQQFG NDISPEIGEK VRTLVLALVN STVTIEEFHC KLQEATNFPL RPFVIPFLKA 180
NLPLLQRELL HCARAAKQTP SQYLAQHEHL LLNTSIASPA DSSELLMEVH GNGKRPSPER 240
REENSFDRDT IAPEPPAKRV CTISPAPRHS PALTVPLMNP GGQFHPTPPP LQHYTLEDIA 300
TSHLYREPNK MLEHREVRDR HHSLGLNGGY QDELVDHRLT EREWADEWKH LDHALNCIME 360
MVEKTRRSMA VLRRCQESDR EELNYWKRRY NENTELRKTG TELVSRQHSP GSADSLSNDS 420
QREFNSRPGT GYVPVEFWKK TEEAVNKVKI QAMSEVQKAV AEAEQKAFEV IATERARMEQ 480
TIADVKRQAA EDAFLVINEQ EESTENCWNC GRKASETCSG CNIARYCGSF CQHKDWERHH 540
RLCGQNLHGQ SPHGQGRPLL PVGRGSSARS ADCSVPSPAL DKTSATTSRS STPASVTAID 600
TNGL 605
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR013289--ETO
IPR013291--MTGR1
IPR014896--NHR2
IPR003894--TAFH_NHR1
IPR002893--Znf_MYND
PROSITE

PS51119--TAFH
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2
Pfam

PF08788--NHR2
PF07531--TAFH
PF01753--zf-MYND
Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0003714--F:transcription corepressor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0030855--P:epithelial cell differentiation
GO:0010977--P:negative regulation of neuron projection development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0010976--P:positive regulation of neuron projection development
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated