dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001539
Uniprot Accession O43432; IF4G3_HUMAN; B9EGQ7; Q15597; Q504Z1; Q5SWC3; Q8NEN1;
Genbank Protein ID NP_001185730.1; NP_001185731.1; NP_001185732.1; NP_003751.2; XP_011540669.1; XP_011540682.1;
Genbank Nucleotide ID NM_001198801.1; NM_001198802.1; NM_001198803.1; NM_003760.4; XM_011542367.1; XM_011542380.1;
Protein Name Eukaryotic translation initiation factor 4 gamma 3
Protein Synonyms/Alias
Gene Name EIF4G3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.
Phosphorylation Sites
 dbPAF PTMs: 39 (View all)
PositionPeptidesSourceReferences ( PMIDs )
119FYPSQPVYQSAPIIVPhosphoSitePlus22135298
164EIMSGGGSRNPTPPIPHOSIDA;curated21081558; 25850435
168GGGSRNPTPPIGRPTPhosphoSitePlus22135298
230KPDPVLKSPSPVLRLdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20068231; 20363803; 21406692;
232DPVLKSPSPVLRLVLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18088087; 19413330; 16381945; 23193290; 19664995;
240PVLRLVLSGEKKEQEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
267AELPLPPSPTTVSSVPhosphoSitePlus;UniProt;curated22135298; 24275569; 23898821
269LPLPPSPTTVSSVARPhosphoSitePlus22135298
305DDRCELSSPREDTIPcurated26074081
487QTEEILDSQNLNSRRcurated25627689; 23898821
492LDSQNLNSRRSPVPAcurated25627689
495QNLNSRRSPVPAQIAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16964243; 17081983; 17693683; 18088087; 18187866; 18669648;
518KPKDRTRTTEEMLEAPhosphoSitePlus22135298
536LKAEEELSIDKVLESPHOSIDA21081558
804EKAIDEPSFSVAYANPhosphoSitePlus22135298
889KDKARRRSIGNIKFIdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
1110ALQPPAPSGSTPSTPcurated22199227
1112QPPAPSGSTPSTPVEPhosphoSitePlus;curated22135298; 22199227
1113PPAPSGSTPSTPVEFPhosphoSitePlus;curated22135298; 25627689
1115APSGSTPSTPVEFDScurated22199227
Sequence
(Fasta)		MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM VNHLPMPYPV 60
PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFPNAYGT PFYPSQPVYQ 120
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPTSTPTP 180
PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS 240
GEKKEQEGQT SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR 300
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV SSTNLINEIN 360
GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE CIPAPITPST VPSFPPTPPT 420
PPASPPHTPV IVPAAATTVS SPSAAITVQR VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ 480
TEEILDSQNL NSRRSPVPAQ IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV 540
LESEQDKMSQ GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS 600
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD VVLDKINQPK 660
LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG SRRSQPGQRR EPRKIITVSV 720
KEDVHLKKAE NAWKPSQKRD SQADDPENIK TQELFRKVRS ILNKLTPQMF NQLMKQVSGL 780
TVDTEERLKG VIDLVFEKAI DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR 840
CQKEFEKDKA DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF 900
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD QYFNQMEKIV 960
KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH KEAKIEEQEE QRKVQQLMTK 1020
EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS KFLKITKPTI DEKIQLVPKA QLGSWGKGSS 1080
GGAKASETDA LRSSASSLNR FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP 1140
LPSATARPNT FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE 1200
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN AQGLLHVFVR 1260
VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS ETLELADDMA IDIPHIWLYL 1320
AELVTPMLKE GGISMRELTI EFSKPLLPVG RAGVLLSEIL HLLCKQMSHK KVGALWREAD 1380
LSWKDFLPEG EDVHNFLLEQ KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN 1440
DEQIFDWVEA NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL 1500
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE SSKDPAEQNG 1560
KGVALKSVTA FFTWLREAEE ESEDN 1586
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0810--Translation regulation
Interpro

IPR016024--ARM-type_fold
IPR003891--Initiation_fac_eIF4g_MI
IPR016021--MIF4-like
IPR003890--MIF4G-like_typ-3
IPR003307--W2_domain
PROSITE

PS51366--MI
PS51363--W2
Pfam

PF02847--MA3
PF02854--MIF4G
PF02020--W2
Gene Ontology

GO:0005829--C:cytosol
GO:0016281--C:eukaryotic translation initiation factor 4F complex
GO:0044822--F:poly(A) RNA binding
GO:0000339--F:RNA cap binding
GO:0008135--F:translation factor activity, RNA binding
GO:0003743--F:translation initiation factor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0006446--P:regulation of translational initiation
GO:0016032--P:viral process