dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001537
Uniprot Accession O43426; SYNJ1_HUMAN; O43425; O94984; Q4KMR1;
Genbank Protein ID NP_001153774.1; NP_001153778.1; NP_003886.3; NP_982271.2;
Genbank Nucleotide ID NM_001160302.1; NM_001160306.1; NM_003895.3; NM_203446.2;
Protein Name Synaptojanin-1
Protein Synonyms/Alias Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1;
Gene Name SYNJ1
Gene Synonyms/Alias KIAA0910;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inositol 5-phosphatase which has a role in clathrin-mediated endocytosis.
Phosphorylation Sites
 dbPAF PTMs: 58 (View all)
PositionPeptidesSourceReferences ( PMIDs )
4----MAFSKGFRIYHPhosphoSitePlus22135298
60YSKVLDAYGLLGVLRPhosphoSitePlus;curated22135298; 22817900
242QVVYLDDSVSSFIQIHPRD 918452278; 18988627
244VYLDDSVSSFIQIRGHPRD 918452278; 18988627
245YLDDSVSSFIQIRGSHPRD 918452278; 18988627
304IIVNLLGSKEGEHMLPhosphoSitePlus22135298
443ISKIYAGTGALEGKAPhosphoSitePlus22135298
498DKARALLTTGSLRVSdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
499KARALLTTGSLRVSEHPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 18988627; 21081558; 22135298; 22817900
501RALLTTGSLRVSEQTHPRD 9;PHOSIDA;curated20068231; 18988627; 21081558
680AIRMLFHTTSLCFVCPhosphoSitePlus22135298
695SHFAAGQSQVKERNEPhosphoSitePlus22135298
786TFAPTYKYDLFSDDYPhosphoPep 2.019060867
830DLDLLNASFQDESKIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19690332; 16381945; 23193290; 18988627; 19060867;
1044GLGTSPSSSPRTSPCPhosphoSitePlus22135298
1045LGTSPSSSPRTSPCQPhosphoSitePlus22135298
1048SPSSSPRTSPCQSPTdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 22135298; 19366988;
1049PSSSPRTSPCQSPTIdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 22135298; 19366988;
1053PRTSPCQSPTISEGPPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25850435; 25627689; 22817900
1055TSPCQSPTISEGPVPcurated23663014
Sequence
(Fasta)		MAFSKGFRIY HKLDPPPFSL IVETRHKEEC LMFESGAVAV LSSAEKEAIK GTYSKVLDAY 60
GLLGVLRLNL GDTMLHYLVL VTGCMSVGKI QESEVFRVTS TEFISLRIDS SDEDRISEVR 120
KVLNSGNFYF AWSASGISLD LSLNAHRSMQ EQTTDNRFFW NQSLHLHLKH YGVNCDDWLL 180
RLMCGGVEIR TIYAAHKQAK ACLISRLSCE RAGTRFNVRG TNDDGHVANF VETEQVVYLD 240
DSVSSFIQIR GSVPLFWEQP GLQVGSHRVR MSRGFEANAP AFDRHFRTLK NLYGKQIIVN 300
LLGSKEGEHM LSKAFQSHLK ASEHAADIQM VNFDYHQMVK GGKAEKLHSV LKPQVQKFLD 360
YGFFYFNGSE VQRCQSGTVR TNCLDCLDRT NSVQAFLGLE MLAKQLEALG LAEKPQLVTR 420
FQEVFRSMWS VNGDSISKIY AGTGALEGKA KLKDGARSVT RTIQNNFFDS SKQEAIDVLL 480
LGNTLNSDLA DKARALLTTG SLRVSEQTLQ SASSKVLKSM CENFYKYSKP KKIRVCVGTW 540
NVNGGKQFRS IAFKNQTLTD WLLDAPKLAG IQEFQDKRSK PTDIFAIGFE EMVELNAGNI 600
VSASTTNQKL WAVELQKTIS RDNKYVLLAS EQLVGVCLFV FIRPQHAPFI RDVAVDTVKT 660
GMGGATGNKG AVAIRMLFHT TSLCFVCSHF AAGQSQVKER NEDFIEIARK LSFPMGRMLF 720
SHDYVFWCGD FNYRIDLPNE EVKELIRQQN WDSLIAGDQL INQKNAGQVF RGFLEGKVTF 780
APTYKYDLFS DDYDTSEKCR TPAWTDRVLW RRRKWPFDRS AEDLDLLNAS FQDESKILYT 840
WTPGTLLHYG RAELKTSDHR PVVALIDIDI FEVEAEERQN IYKEVIAVQG PPDGTVLVSI 900
KSSLPENNFF DDALIDELLQ QFASFGEVIL IRFVEDKMWV TFLEGSSALN VLSLNGKELL 960
NRTITIALKS PDWIKNLEEE MSLEKISIAL PSSTSSTLLG EDAEVAADFD MEGDVDDYSA 1020
EVEELLPQHL QPSSSSGLGT SPSSSPRTSP CQSPTISEGP VPSLPIRPSR APSRTPGPPS 1080
AQSSPIDAQP ATPLPQKDPA QPLEPKRPPP PRPVAPPTRP APPQRPPPPS GARSPAPTRK 1140
EFGGIGAPPS PGVARREMEA PKSPGTTRKD NIGRSQPSPQ AGLAGPGPAG YSTARPTIPP 1200
RAGVISAPQS HARASAGRLT PESQSKTSET SKGSTFLPEP LKPQAAFPPQ SSLPPPAQRL 1260
QEPLVPVAAP MPQSGPQPNL ETPPQPPPRS RSSHSLPSEA SSQPQVKTNG ISDGKRESPL 1320
KIDPFEDLSF NLLAVSKAQL SVQTSPVPTP DPKRLIQLPS ATQSNVLSSV SCMPTMPPIP 1380
ARSQSQENMR SSPNPFITGL TRTNPFSDRT AAPGNPFRAK SEESEATSWF SKEEPVTISP 1440
FPSLQPLGHN KSRASSSLDG FKDSFDLQGQ STLKISNPKG WVTFEEEEDF GVKGKSKSAC 1500
SDLLGNQPSS FSGSNLTLND DWNKGTNVSF CVLPSRRPPP PPVPLLPPGT SPPVDPFTTL 1560
ASKASPTLDF TER 1574
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0523--Neurodegeneration
KW-0907--Parkinson disease
KW-0908--Parkinsonism
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
Interpro

IPR015047--DUF1866
IPR005135--Endo/exonuclease/phosphatase
IPR000300--IPPc
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR002013--SAC_dom
PROSITE

PS50102--RRM
PS50275--SAC
Pfam

PF08952--DUF1866
PF03372--Exo_endo_phos
PF02383--Syja_N
Gene Ontology

GO:0005829--C:cytosol
GO:0030117--C:membrane coat
GO:0004445--F:inositol-polyphosphate 5-phosphatase activity
GO:0000166--F:nucleotide binding
GO:0034595--F:phosphatidylinositol phosphate 5-phosphatase activity
GO:0004439--F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0003723--F:RNA binding
GO:0046855--P:inositol phosphate dephosphorylation
GO:0043647--P:inositol phosphate metabolic process
GO:0006836--P:neurotransmitter transport
GO:0006796--P:phosphate-containing compound metabolic process
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0046856--P:phosphatidylinositol dephosphorylation
GO:0046488--P:phosphatidylinositol metabolic process
GO:0006644--P:phospholipid metabolic process
GO:1903390--P:positive regulation of synaptic vesicle uncoating
GO:1901632--P:regulation of synaptic vesicle membrane organization
GO:0044281--P:small molecule metabolic process
GO:0048488--P:synaptic vesicle endocytosis
GO:0016082--P:synaptic vesicle priming
GO:0048489--P:synaptic vesicle transport
GO:0016191--P:synaptic vesicle uncoating