| Tag |
Content |
| dbPAF ID |
dbPAF-0001536 |
| Uniprot Accession |
O43424; GRID2_HUMAN; E9PH24; Q4KKU8; Q4KKU9; Q4KKV0; Q59FZ1;
|
| Genbank Protein ID |
NP_001273767.1; NP_001501.2;
|
| Genbank Nucleotide ID |
NM_001286838.1; NM_001510.3;
|
| Protein Name |
Glutamate receptor ionotropic, delta-2 |
| Protein Synonyms/Alias |
|
| Gene Name |
GRID2 |
| Gene Synonyms/Alias |
GLURD2; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.Functional Description
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MEVFPFLLVL SVWWSRTWDS ANADSIIHIG AIFDESAKKD DEVFRTAVGD LNQNEEILQT 60
EKITFSVTFV DGNNPFQAVQ EACELMNQGI LALVSSIGCT SAGSLQSLAD AMHIPHLFIQ 120
RSTAGTPRSG CGLTRSNRND DYTLSVRPPV YLHDVILRVV TEYAWQKFII FYDSEYDIRG 180
IQEFLDKVSQ QGMDVALQKV ENNINKMITT LFDTMRIEEL NRYRDTLRRA ILVMNPATAK 240
SFITEVVETN LVAFDCHWII INEEINDVDV QELVRRSIGR LTIIRQTFPV PQNISQRCFR 300
GNHRISSTLC DPKDPFAQNM EISNLYIYDT VLLLANAFHK KLEDRKWHSM ASLSCIRKNS 360
KPWQGGRSML ETIKKGGVSG LTGELEFGEN GGNPNVHFEI LGTNYGEELG RGVRKLGCWN 420
PVTGLNGSLT DKKLENNMRG VVLRVVTVLE EPFVMVSENV LGKPKKYQGF SIDVLDALSN 480
YLGFNYEIYV APDHKYGSPQ EDGTWNGLVG ELVFKRADIG ISALTITPDR ENVVDFTTRY 540
MDYSVGVLLR RAEKTVDMFA CLAPFDLSLW ACIAGTVLLV GLLVYLLNWL NPPRLQMGSM 600
TSTTLYNSMW FVYGSFVQQG GEVPYTTLAT RMMMGAWWLF ALIVISSYTA NLAAFLTITR 660
IESSIQSLQD LSKQTEIPYG TVLDSAVYEH VRMKGLNPFE RDSMYSQMWR MINRSNGSEN 720
NVLESQAGIQ KVKYGNYAFV WDAAVLEYVA INDPDCSFYT IGNTVADRGY GIALQHGSPY 780
RDVFSQRILE LQQNGDMDIL KHKWWPKNGQ CDLYSSVDTK QKGGALDIKS FAGVFCILAA 840
GIVLSCFIAM LETWWNKRKG SRVPSKEDDK EIDLEHLHRR VNSLCTDDDS PHKQFSTSSI 900
DLTPLDIDTL PTRQALEQIS DFRNTHITTT TFIPEQIQTL SRTLSAKAAS GFTFGNVPEH 960
RTGPFRHRAP NGGFFRSPIK TMSSIPYQPT PTLGLNLGND PDRGTSI
1008Fasta Sequence
>O43424|GRID2|Homo sapiens(Human)
MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI
|
| Keyword |
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0407--Ion channel
KW-0406--Ion transport
KW-1071--Ligand-gated ion channel
KW-0472--Membrane
KW-0523--Neurodegeneration
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0628--Postsynaptic cell membrane
KW-0675--Receptor
KW-1185--Reference proteome
KW-0732--Signal
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR001828--ANF_lig-bd_rcpt
IPR019594--Glu/Gly-bd
IPR001508--Iono_rcpt_met
IPR001320--Iontro_rcpt
IPR028082--Peripla_BP_I
|
| PROSITE |
|
| Pfam |
PF01094--ANF_receptor
PF00060--Lig_chan
PF10613--Lig_chan-Glu_bd
|
| Gene Ontology |
GO:0030054--C:cell junction
GO:0030425--C:dendrite
GO:0043197--C:dendritic spine
GO:0005887--C:integral component of plasma membrane
GO:0008328--C:ionotropic glutamate receptor complex
GO:0005886--C:plasma membrane
GO:0045211--C:postsynaptic membrane
GO:0045202--C:synapse
GO:0005234--F:extracellular-glutamate-gated ion channel activity
GO:0008066--F:glutamate receptor activity
GO:0004970--F:ionotropic glutamate receptor activity
GO:0030165--F:PDZ domain binding
GO:0097110--F:scaffold protein binding
GO:0034613--P:cellular protein localization
GO:0021707--P:cerebellar granule cell differentiation
GO:0060079--P:excitatory postsynaptic potential
GO:0007215--P:glutamate receptor signaling pathway
GO:0007157--P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0034220--P:ion transmembrane transport
GO:0035235--P:ionotropic glutamate receptor signaling pathway
GO:0060134--P:prepulse inhibition
GO:0043523--P:regulation of neuron apoptotic process
GO:0010975--P:regulation of neuron projection development
GO:0035249--P:synaptic transmission, glutamatergic
GO:0006810--P:transport
|
