dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001534
Uniprot Accession O43422; P52K_HUMAN; A8K728; Q17RY9; Q8WTW1; Q9Y3Z4;
Genbank Protein ID NP_004696.2;
Genbank Nucleotide ID NM_004705.3;
Protein Name 52 kDa repressor of the inhibitor of the protein kinase
Protein Synonyms/Alias
Gene Name PRKRIR
Gene Synonyms/Alias DAP4;P52RIPK;THAP0;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
47RADLEDKTPDQLNKHPhosphoSitePlus22135298
71TSMICRTSPYRTVLRcurated23898821
97SHLNNPHSRHRKRIKPhosphoSitePlus22135298
107RKRIKELSEDEIRTLPhosphoSitePlus;curated22135298; 25627689
132QEQKHKETNNSNAQNcurated23663014
135KHKETNNSNAQNPSEcurated23663014
141NSNAQNPSEEEGEGQPhosphoSitePlus;curated22135298; 25850435; 25627689; 23898821; 20873877; 22817900;
330EYCRGQAYIVSSGFSPhosphoSitePlus22135298
345SKMKVVASRLLEKYPPhosphoSitePlus22135298
513DVFFAAGSLTAVLHSPhosphoSitePlus22135298
515FFAAGSLTAVLHSLNPhosphoSitePlus22135298
566AHQGNLESQLTSESYPhosphoSitePlus;curated22135298; 23186163
579SYYKETLSVPTVEHIPhosphoSitePlus22135298
595QELKDIFSEQHLKALPhosphoSitePlus22135298
606LKALKCLSLVPSVMGPhosphoSitePlus22135298
610KCLSLVPSVMGQLKFdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
755SELPTDNSETVENT-curated25627689
Sequence
(Fasta)		MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ LNKHYRLCAK 60
HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR KRIKELSEDE IRTLKQKKID 120
ETSEQEQKHK ETNNSNAQNP SEEEGEGQDE DILPLTLEEK ENKEYLKSLF EILILMGKQN 180
IPLDGHEADE IPEGLFTPDN FQALLECRIN SGEEVLRKRF ETTAVNTLFC SKTQQRQMLE 240
ICESCIREET LREVRDSHFF SIITDDVVDI AGEEHLPVLV RFVDESHNLR EEFIGFLPYE 300
ADAEILAVKF HTMITEKWGL NMEYCRGQAY IVSSGFSSKM KVVASRLLEK YPQAIYTLCS 360
SCALNMWLAK SVPVMGVSVA LGTIEEVCSF FHRSPQLLLE LDNVISVLFQ NSKERGKELK 420
EICHSQWTGR HDAFEILVEL LQALVLCLDG INSDTNIRWN NYIAGRAFVL CSAVSDFDFI 480
VTIVVLKNVL SFTRAFGKNL QGQTSDVFFA AGSLTAVLHS LNEVMENIEV YHEFWFEEAT 540
NLATKLDIQM KLPGKFRRAH QGNLESQLTS ESYYKETLSV PTVEHIIQEL KDIFSEQHLK 600
ALKCLSLVPS VMGQLKFNTS EEHHADMYRS DLPNPDTLSA ELHCWRIKWK HRGKDIELPS 660
TIYEALHLPD IKFFPNVYAL LKVLCILPVM KVENERYENG RKRLKAYLRN TLTDQRSSNL 720
ALLNINFDIK HDLDLMVDTY IKLYTSKSEL PTDNSETVEN T 762
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR025398--DUF4371
IPR008906--HATC_dom_C
IPR012337--RNaseH-like_dom
IPR006612--Znf_C2CH
PROSITE

PS50950--ZF_THAP
Pfam

PF05699--Dimer_Tnp_hAT
PF14291--DUF4371
PF05485--THAP
Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0008285--P:negative regulation of cell proliferation
GO:0006950--P:response to stress
GO:0007165--P:signal transduction