Tag |
Content |
dbPAF ID |
dbPAF-0001532 |
Uniprot Accession |
O43405; COCH_HUMAN; A8K9K9; D3DS84; Q96IU6; |
Genbank Protein ID |
NP_001128530.1; NP_004077.1; XP_011534841.1; |
Genbank Nucleotide ID |
NM_001135058.1; NM_004086.2; XM_011536539.1; |
Protein Name |
Cochlin |
Protein Synonyms/Alias |
COCH-5B2; |
Gene Name |
COCH |
Gene Synonyms/Alias |
COCH5B2;UNQ257/PRO294; |
Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Plays a role in the control of cell shape and motility in the trabecular meshwork.Functional Description
Plays a role in the control of cell shape and motility in the trabecular meshwork.
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Phosphorylation Sites
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dbPAF PTMs: 6 Position | Peptides | Source | References ( PMIDs ) |
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120 | MLSRWSASFTVTKGK | PhosphoSitePlus | 22135298 | 122 | SRWSASFTVTKGKSS | PhosphoSitePlus | 22135298 | 124 | WSASFTVTKGKSSTQ | PhosphoSitePlus | 22135298 | 129 | TVTKGKSSTQEATGQ | PhosphoSitePlus | 22135298 | 339 | HMPNWFGTTKYVKPL | PhosphoSitePlus | 22135298 | 340 | MPNWFGTTKYVKPLV | PhosphoSitePlus | 22135298 |
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Sequence (Fasta) | MSAAWIPALG LGVCLLLLPG PAGSEGAAPI AITCFTRGLD IRKEKADVLC PGGCPLEEFS 60 VYGNIVYASV SSICGAAVHR GVISNSGGPV RVYSLPGREN YSSVDANGIQ SQMLSRWSAS 120 FTVTKGKSST QEATGQAVST AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR 180 FNLQKNFVGK VALMLGIGTE GPHVGLVQAS EHPKIEFYLK NFTSAKDVLF AIKEVGFRGG 240 NSNTGKALKH TAQKFFTVDA GVRKGIPKVV VVFIDGWPSD DIEEAGIVAR EFGVNVFIVS 300 VAKPIPEELG MVQDVTFVDK AVCRNNGFFS YHMPNWFGTT KYVKPLVQKL CTHEQMMCSK 360 TCYNSVNIAF LIDGSSSVGD SNFRLMLEFV SNIAKTFEIS DIGAKIAAVQ FTYDQRTEFS 420 FTDYSTKENV LAVIRNIRYM SGGTATGDAI SFTVRNVFGP IRESPNKNFL VIVTDGQSYD 480 DVQGPAAAAH DAGITIFSVG VAWAPLDDLK DMASKPKESH AFFTREFTGL EPIVSDVIRG 540 ICRDFLESQQ
551Fasta Sequence
>O43405|COCH|Homo sapiens(Human) MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ
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Keyword |
KW-0002--3D-structure KW-0025--Alternative splicing KW-0181--Complete proteome KW-0209--Deafness KW-0225--Disease mutation KW-1015--Disulfide bond KW-0272--Extracellular matrix KW-0325--Glycoprotein KW-1009--Hearing KW-1010--Non-syndromic deafness KW-0621--Polymorphism KW-1185--Reference proteome KW-0677--Repeat KW-0964--Secreted KW-0732--Signal
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Interpro |
IPR030743--Cochlin IPR004043--LCCL IPR002035--VWF_A
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PROSITE |
PS50820--LCCL PS50234--VWFA
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Pfam |
PF03815--LCCL PF00092--VWA
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Gene Ontology |
GO:0070062--C:extracellular exosome GO:0031012--C:extracellular matrix GO:0005578--C:proteinaceous extracellular matrix GO:0005518--F:collagen binding GO:0042742--P:defense response to bacterium GO:0045089--P:positive regulation of innate immune response GO:0008360--P:regulation of cell shape GO:0007605--P:sensory perception of sound
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