dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001532
Uniprot Accession O43405; COCH_HUMAN; A8K9K9; D3DS84; Q96IU6;
Genbank Protein ID NP_001128530.1; NP_004077.1; XP_011534841.1;
Genbank Nucleotide ID NM_001135058.1; NM_004086.2; XM_011536539.1;
Protein Name Cochlin
Protein Synonyms/Alias COCH-5B2;
Gene Name COCH
Gene Synonyms/Alias COCH5B2;UNQ257/PRO294;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Plays a role in the control of cell shape and motility in the trabecular meshwork.
Phosphorylation Sites
dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
120MLSRWSASFTVTKGKPhosphoSitePlus22135298
122SRWSASFTVTKGKSSPhosphoSitePlus22135298
124WSASFTVTKGKSSTQPhosphoSitePlus22135298
129TVTKGKSSTQEATGQPhosphoSitePlus22135298
339HMPNWFGTTKYVKPLPhosphoSitePlus22135298
340MPNWFGTTKYVKPLVPhosphoSitePlus22135298
Sequence
(Fasta)
MSAAWIPALG LGVCLLLLPG PAGSEGAAPI AITCFTRGLD IRKEKADVLC PGGCPLEEFS 60
VYGNIVYASV SSICGAAVHR GVISNSGGPV RVYSLPGREN YSSVDANGIQ SQMLSRWSAS 120
FTVTKGKSST QEATGQAVST AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR 180
FNLQKNFVGK VALMLGIGTE GPHVGLVQAS EHPKIEFYLK NFTSAKDVLF AIKEVGFRGG 240
NSNTGKALKH TAQKFFTVDA GVRKGIPKVV VVFIDGWPSD DIEEAGIVAR EFGVNVFIVS 300
VAKPIPEELG MVQDVTFVDK AVCRNNGFFS YHMPNWFGTT KYVKPLVQKL CTHEQMMCSK 360
TCYNSVNIAF LIDGSSSVGD SNFRLMLEFV SNIAKTFEIS DIGAKIAAVQ FTYDQRTEFS 420
FTDYSTKENV LAVIRNIRYM SGGTATGDAI SFTVRNVFGP IRESPNKNFL VIVTDGQSYD 480
DVQGPAAAAH DAGITIFSVG VAWAPLDDLK DMASKPKESH AFFTREFTGL EPIVSDVIRG 540
ICRDFLESQQ 551
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0209--Deafness
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0272--Extracellular matrix
KW-0325--Glycoprotein
KW-1009--Hearing
KW-1010--Non-syndromic deafness
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal

Interpro

IPR030743--Cochlin
IPR004043--LCCL
IPR002035--VWF_A

PROSITE

PS50820--LCCL
PS50234--VWFA

Pfam

PF03815--LCCL
PF00092--VWA

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0031012--C:extracellular matrix
GO:0005578--C:proteinaceous extracellular matrix
GO:0005518--F:collagen binding
GO:0042742--P:defense response to bacterium
GO:0045089--P:positive regulation of innate immune response
GO:0008360--P:regulation of cell shape
GO:0007605--P:sensory perception of sound