dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001529
Uniprot Accession O43396; TXNL1_HUMAN;
Genbank Protein ID NP_004777.1;
Genbank Nucleotide ID NM_004786.2;
Protein Name Thioredoxin-like protein 1
Protein Synonyms/Alias 32 kDa thioredoxin-related protein;
Gene Name TXNL1
Gene Synonyms/Alias TRP32;TXL;TXNL;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Active thioredoxin with a redox potential of about -250 mV.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
9VGVKPVGSDPDFQPEPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23917254
18PDFQPELSGAGSRLAdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
22PELSGAGSRLAVVKFPHOSIDA21081558
46RIAPAFSSMSNKYPQdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
48APAFSSMSNKYPQAVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
113HLENDPGSNEDTDIPdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated20166139; 20363803; 21406692; 22115753; 16381945; 23193290;
117DPGSNEDTDIPKGYMdbPTM 3.0;HPRD 9;PhosphoSitePlus20166139; 16381945; 23193290; 18988627; 22135298
141GCECLNESDEHGFDNPhosphoSitePlus22135298
258NQGEEETTRISYFTFPHOSIDA;curated21081558; 20068231
262EETTRISYFTFIGTPdbPTM 3.0;PhosphoSitePlus;curated19702290; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK YPQAVFLEVD 60
VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE EKIKQHLEND PGSNEDTDIP 120
KGYMDLMPFI NKAGCECLNE SDEHGFDNCL RKDTTFLESD CDEQLLITVA FNQPVKLYSM 180
KFQGPDNGQG PKYVKIFINL PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN 240
VNSVTIFVQS NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0249--Electron transport
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-0676--Redox-active center
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR008979--Galactose-bd-like
IPR010400--PITH_dom
IPR005746--Thioredoxin
IPR012336--Thioredoxin-like_fold
IPR017937--Thioredoxin_CS
IPR013766--Thioredoxin_domain
PROSITE

PS51532--PITH
PS00194--THIOREDOXIN_1
Pfam

PF06201--PITH
PF00085--Thioredoxin
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0015036--F:disulfide oxidoreductase activity
GO:0016671--F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0015035--F:protein disulfide oxidoreductase activity
GO:0045454--P:cell redox homeostasis
GO:0034599--P:cellular response to oxidative stress
GO:0006662--P:glycerol ether metabolic process
GO:0055114--P:oxidation-reduction process
GO:0006457--P:protein folding
GO:0000103--P:sulfate assimilation