dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001528
Uniprot Accession O43395; PRPF3_HUMAN; B4DSY9; O43446; Q5VT54;
Genbank Protein ID NP_004689.1;
Genbank Nucleotide ID NM_004698.2;
Protein Name U4/U6 small nuclear ribonucleoprotein Prp3
Protein Synonyms/Alias Pre-mRNA-splicing factor 3;hPrp3;U4/U6 snRNP 90 kDa protein;
Gene Name PRPF3
Gene Synonyms/Alias HPRP3;PRP3;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
Phosphorylation Sites
 dbPAF PTMs: 24 (View all)
PositionPeptidesSourceReferences ( PMIDs )
102FGDDSEISKESSGVKPhosphoSitePlus22135298
105DSEISKESSGVKKRRdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
106SEISKESSGVKKRRIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 22135298; 22817900
131EVIPGPPSESPGMLTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;curated18669648; 16381945; 23193290; 20068231; 18988627; 25627689;
133IPGPPSESPGMLTKLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated16565220; 19007248; 16381945; 23193290; 18669648; 20068231;
138SESPGMLTKLQIKQMPhosphoSitePlus;curated22135298; 22199227
161EERKKQLSFISPPTPdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900;
164KKQLSFISPPTPQPKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19413330; 16381945; 23193290; 20068231; 18988627;
167LSFISPPTPQPKTPSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19413330; 16381945; 23193290; 16964243; 18847512;
172PPTPQPKTPSSSQPEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 20068231; 18988627; 22135298;
175PQPKTPSSSQPERLPdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
176QPKTPSSSQPERLPIdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
264ILDEQGRTVDATGKEdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 22817900
356EKLQAEISQAARKTGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated17525332; 16381945; 23193290; 18988627; 19060867; 22135298;
411ENPKREDYFGITNLVdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
415REDYFGITNLVEHPAdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
432NPPVDNDTPVTLGVYPhosphoSitePlus;curated22135298; 25627689
479PEPKVRISNLMRVLGdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 22817900
494TEAVQDPTKVEAHVRdbPTM 3.0;PhosphoSitePlus;curated17932117; 16381945; 23193290; 22135298; 22817900
608RIKWDEQTSNTKGDDcurated23917254; 20873877
Sequence
(Fasta)		MALSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH LKPFLDDSTL 60
RFVDKLFEAV EEGRSSRHSK SSSDRSRKRE LKEVFGDDSE ISKESSGVKK RRIPRFEEVE 120
EEPEVIPGPP SESPGMLTKL QIKQMMEAAT RQIEERKKQL SFISPPTPQP KTPSSSQPER 180
LPIGNTIQPS QAATFMNDAI EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI 240
APPKVELKDQ TKPTPLILDE QGRTVDATGK EIELTHRMPT LKANIRAVKR EQFKQQLKEK 300
PSEDMESNTF FDPRVSIAPS QRQRRTFKFH DKGKFEKIAQ RLRTKAQLEK LQAEISQAAR 360
KTGIHTSTRL ALIAPKKELK EGDIPEIEWW DSYIIPNGFD LTEENPKRED YFGITNLVEH 420
PAQLNPPVDN DTPVTLGVYL TKKEQKKLRR QTRREAQKEL QEKVRLGLMP PPEPKVRISN 480
LMRVLGTEAV QDPTKVEAHV RAQMAKRQKA HEEANAARKL TAEQRKVKKI KKLKEDISQG 540
VHISVYRVRN LSNPAKKFKI EANAGQLYLT GVVVLHKDVN VVVVEGGPKA QKKFKRLMLH 600
RIKWDEQTSN TKGDDDEESD EEAVKKTNKC VLVWEGTAKD RSFGEMKFKQ CPTENMAREH 660
FKKHGAEHYW DLALSESVLE STD 684
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0682--Retinitis pigmentosa
KW-0747--Spliceosome
KW-0832--Ubl conjugation
Interpro

IPR010541--DUF1115
IPR013881--Pre-mRNA_splic_Prp3
IPR027104--Prp3
IPR002483--PWI_dom
PROSITE

PS51025--PWI
Pfam

PF06544--DUF1115
PF08572--PRP3
PF01480--PWI
Gene Ontology

GO:0015030--C:Cajal body
GO:0005737--C:cytoplasm
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0042802--F:identical protein binding
GO:0044822--F:poly(A) RNA binding
GO:0006397--P:mRNA processing
GO:0000398--P:mRNA splicing, via spliceosome
GO:0008380--P:RNA splicing
GO:0000375--P:RNA splicing, via transesterification reactions
GO:0000244--P:spliceosomal tri-snRNP complex assembly