dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001527
Uniprot Accession O43390; HNRPR_HUMAN; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4;
Genbank Protein ID NP_001095868.1; NP_001284549.1; NP_005817.1; XP_005245768.1; XP_011538773.1;
Genbank Nucleotide ID NM_001102398.2; NM_001297620.1; NM_005826.4; XM_005245711.3; XM_011540471.1;
Protein Name Heterogeneous nuclear ribonucleoprotein R
Protein Synonyms/Alias
Gene Name HNRNPR
Gene Synonyms/Alias HNRPR;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.
Phosphorylation Sites
 dbPAF PTMs: 36 (View all)
PositionPeptidesSourceReferences ( PMIDs )
21EEEEPMDTSSVTHTEcurated25627689; 20873877
22EEEPMDTSSVTHTEHPhosphoSitePlus;curated22135298; 25627689; 23186163; 20873877
23EEPMDTSSVTHTEHYPhosphoSitePlus;curated22135298; 25627689; 20873877; 24961811
32THTEHYKTLIEAGLPPhosphoSitePlus;curated22135298; 25627689
52RLDEIFQTGLVAYVDPhosphoSitePlus;curated22135298; 23836654
78FNEEGALSVLQQFKEPhosphoSitePlus22135298
95LSHVQNKSAFLCGVMPhosphoSitePlus22135298
141TGYTLDVTTGQRKYGPhosphoSitePlus22135298
147VTTGQRKYGGPPPDSPhosphoSitePlus22135298
177GKIPRDLYEDELVPLPhosphoSitePlus22135298
208LSGQNRGYAFITFCGdbPTM 3.0;PhosphoSitePlus20090780; 16381945; 23193290; 22135298
228EAVKLCDSYEIRPGKPhosphoSitePlus;curated22135298; 25627689
229AVKLCDSYEIRPGKHdbPTM 3.0;PhosphoSitePlus20090780; 16381945; 23193290; 22135298
252NNRLFVGSIPKNKTKdbPTM 3.0;PhosphoSitePlus;curated20068231; 21406692; 16381945; 23193290; 22135298; 25850435;
296RGFCFLEYEDHKSAAPhosphoSitePlus;curated22135298; 25627689
360TEEILEKSFSEFGKLcurated23090842
362EILEKSFSEFGKLERPhosphoSitePlus;curated22135298; 22199227
376RVKKLKDYAFVHFEDPhosphoSitePlus22135298
426RQAARQASRSTAYEDPhosphoSitePlus22135298
428AARQASRSTAYEDYYPhosphoSitePlus22135298
Sequence
(Fasta)		MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL 60
DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK 120
GPDEAKIKAL LERTGYTLDV TTGQRKYGGP PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE 180
LVPLFEKAGP IWDLRLMMDP LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC 240
ISVANNRLFV GSIPKNKTKE NILEEFSKVT EGLVDVILYH QPDDKKKNRG FCFLEYEDHK 300
SAAQARRRLM SGKVKVWGNV VTVEWADPVE EPDPEVMAKV KVLFVRNLAT TVTEEILEKS 360
FSEFGKLERV KKLKDYAFVH FEDRGAAVKA MDEMNGKEIE GEEIEIVLAK PPDKKRKERQ 420
AARQASRSTA YEDYYYHPPP RMPPPIRGRG RGGGRGGYGY PPDYYGYEDY YDDYYGYDYH 480
DYRGGYEDPY YGYDDGYAVR GRGGGRGGRG APPPPRGRGA PPPRGRAGYS QRGAPLGPPR 540
GSRGGRGGPA QQQRGRGSRG SRGNRGGNVG GKRKADGYNQ PDSKRRQTNN QQNWGSQPIA 600
QQPLQQGGDY SGNYGYNNDN QEFYQDTYGQ QWK 634
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0747--Spliceosome
KW-0832--Ubl conjugation
Interpro

IPR006535--HnRNP_R/Q_splicing_fac
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
PROSITE

PS50102--RRM
Pfam

PF00076--RRM_1
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0030529--C:ribonucleoprotein complex
GO:0005681--C:spliceosomal complex
GO:0000166--F:nucleotide binding
GO:0044822--F:poly(A) RNA binding
GO:0003723--F:RNA binding
GO:0010467--P:gene expression
GO:0006397--P:mRNA processing
GO:0000398--P:mRNA splicing, via spliceosome
GO:0008380--P:RNA splicing