dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001526
Uniprot Accession O43379; WDR62_HUMAN; Q63HP9; Q659D7; Q8NBF7; Q96AD9;
Genbank Protein ID NP_001077430.1; NP_775907.4;
Genbank Nucleotide ID NM_001083961.1; NM_173636.4;
Protein Name WD repeat-containing protein 62
Protein Synonyms/Alias
Gene Name WDR62
Gene Synonyms/Alias C19orf14;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806).
Phosphorylation Sites
 dbPAF PTMs: 78 (View all)
PositionPeptidesSourceReferences ( PMIDs )
6--MAAVGSGGYARNDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19007248; 16381945; 23193290; 19691289; 18988627; 22135298;
9AAVGSGGYARNDAGEdbPTM 3.0;HPRD 9;curated19007248; 16381945; 23193290; 20068231; 18988627; 22199227;
32VPARRGQSSPPPAPPPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 25627689; 23911959; 23898821; 25404012;
33PARRGQSSPPPAPPIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated15302935; 19007248; 19413330; 16381945; 23193290; 19664994;
46PICLRRRTRLSTASEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;UniProt;curated18669648; 16381945; 23193290; 19691289; 21406692; 20068231;
49LRRRTRLSTASEETVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19007248; 19690332; 16381945; 23193290; 19691289;
50RRRTRLSTASEETVQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19690332; 16381945; 23193290; 19691289; 20068231;
52RTRLSTASEETVQNRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19007248; 16381945; 23193290; 19691289; 20068231;
55LSTASEETVQNRVSLPhosphoSitePlus22135298
113IFNTARKSLSALAFSPhosphoSitePlus22135298
120SLSALAFSPDGKYIVPhosphoSitePlus22135298
156AEMLGHKYGVACVAFdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
164GVACVAFSPNMKHIVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
444IRFWNLDSSPDSHWQcurated25627689
445RFWNLDSSPDSHWQKPhosphoSitePlus;curated22135298; 25627689
501GVRVMQVSPDGQHLAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19007248; 16381945; 23193290; 19691289; 20068231;
513HLASGDRSGNLRIHEcurated22817900
598NRDIQMISCGADKSIPhosphoSitePlus;curated22135298; 22817900
614FRSAQQGSDGLHFVRdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19691289; 16381945; 23193290; 18988627; 22135298; 25627689;
666NGKQKKCYKGSQGDEPhosphoSitePlus22135298
Sequence
(Fasta)		MAAVGSGGYA RNDAGEKLPS VMAGVPARRG QSSPPPAPPI CLRRRTRLST ASEETVQNRV 60
SLEKVLGITA QNSSGLTCDP GTGHVAYLAG CVVVILDPKE NKQQHIFNTA RKSLSALAFS 120
PDGKYIVTGE NGHRPAVRIW DVEEKNQVAE MLGHKYGVAC VAFSPNMKHI VSMGYQHDMV 180
LNVWDWKKDI VVASNKVSCR VIALSFSEDS SYFVTVGNRH VRFWFLEVST ETKVTSTVPL 240
VGRSGILGEL HNNIFCGVAC GRGRMAGSTF CVSYSGLLCQ FNEKRVLEKW INLKVSLSSC 300
LCVSQELIFC GCTDGIVRIF QAHSLHYLAN LPKPHYLGVD VAQGLEPSFL FHRKAEAVYP 360
DTVALTFDPI HQWLSCVYKD HSIYIWDVKD INRVGKVWSE LFHSSYVWNV EVYPEFEDQR 420
ACLPSGSFLT CSSDNTIRFW NLDSSPDSHW QKNIFSNTLL KVVYVENDIQ HLQDMSHFPD 480
RGSENGTPMD VKAGVRVMQV SPDGQHLASG DRSGNLRIHE LHFMDELVKV EAHDAEVLCL 540
EYSKPETGLT LLASASRDRL IHVLNVEKNY NLEQTLDDHS SSITAIKFAG NRDIQMISCG 600
ADKSIYFRSA QQGSDGLHFV RTHHVAEKTT LYDMDIDITQ KYVAVACQDR NVRVYNTVNG 660
KQKKCYKGSQ GDEGSLLKVH VDPSGTFLAT SCSDKSISVI DFYSGECIAK MFGHSEIITS 720
MKFTYDCHHL ITVSGDSCVF IWHLGPEITN CMKQHLLEID HRQQQQHTND KKRSGHPRQD 780
TYVSTPSEIH SLSPGEQTED DLEEECEPEE MLKTPSKDSL DPDPRCLLTN GKLPLWAKRL 840
LGDDDVADGL AFHAKRSYQP HGRWAERAGQ EPLKTILDAQ DLDCYFTPMK PESLENSILD 900
SLEPQSLASL LSESESPQEA GRGHPSFLPQ QKESSEASEL ILYSLEAEVT VTGTDSQYCR 960
KEVEAGPGDQ QGDSYLRVSS DSPKDQSPPE DSGESEADLE CSFAAIHSPA PPPDPAPRFA 1020
TSLPHFPGCA GPTEDELSLP EGPSVPSSSL PQTPEQEKFL RHHFETLTES PCRALGDVEA 1080
SEAEDHFFNP RLSISTQFLS SLQKASRFTH TFPPRATQCL VKSPEVKLMD RGGSQPRAGT 1140
GYASPDRTHV LAAGKAEETL EAWRPPPPCL TSLASCVPAS SVLPTDRNLP TPTSAPTPGL 1200
AQGVHAPSTC SYMEATASSR ARISRSISLG DSEGPIVATL AQPLRRPSSV GELASLGQEL 1260
QAITTATTPS LDSEGQEPAL RSWGNHEARA NLRLTLSSAC DGLLQPPVDT QPGVTVPAVS 1320
FPAPSPVEES ALRLHGSAFR PSLPAPESPG LPAHPSNPQL PEARPGIPGG TASLLEPTSG 1380
ALGLLQGSPA RWSEPWVPVE ALPPSPLELS RVGNILHRLQ TTFQEALDLY RVLVSSGQVD 1440
TGQQQARTEL VSTFLWIHSQ LEAECLVGTS VAPAQALPSP GPPSPPTLYP LASPDLQALL 1500
EHYSELLVQA VRRKARGH 1519
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0905--Primary microcephaly
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR030545--WDR62
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0021987--P:cerebral cortex development
GO:0007052--P:mitotic spindle organization
GO:0022008--P:neurogenesis