| Tag |
Content |
| dbPAF ID |
dbPAF-0001525 |
| Uniprot Accession |
O43374; RASL2_HUMAN; O60286; Q14CQ4; Q86UW3; Q96QU0;
|
| Genbank Protein ID |
NP_001073346.2; NP_008920.5;
|
| Genbank Nucleotide ID |
NM_001079877.2; NM_006989.5;
|
| Protein Name |
Ras GTPase-activating protein 4 |
| Protein Synonyms/Alias |
Calcium-promoted Ras inactivator;Ras p21 protein activator 4;RasGAP-activating-like protein 2; |
| Gene Name |
RASA4 |
| Gene Synonyms/Alias |
CAPRI;GAPL;KIAA0538; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.Functional Description
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MAKRSSLYIR IVEGKNLPAK DITGSSDPYC IVKVDNEPII RTATVWKTLC PFWGEEYQVH 60
LPPTFHAVAF YVMDEDALSR DDVIGKVCLT RDTIASHPKG FSGWAHLTEV DPDEEVQGEI 120
HLRLEVWPGA RACRLRCSVL EARDLAPKDR NGTSDPFVRV RYKGRTRETS IVKKSCYPRW 180
NETFEFELQE GAMEALCVEA WDWDLVSRND FLGKVVIDVQ RLRVVQQEEG WFRLQPDQSK 240
SRRHDEGNLG SLQLEVRLRD ETVLPSSYYQ PLVHLLCHEV KLGMQGPGQL IPLIEETTST 300
ECRQDVATNL LKLFLGQGLA KDFLDLLFQL ELSRTSETNT LFRSNSLASK SMESFLKVAG 360
MQYLHGVLGP IINKVFEEKK YVELDPSKVE VKDVGCSGLH RPQTEAEVLE QSAQTLRAHL 420
GALLSALSRS VRACPAVVRA TFRQLFRRVR ERFPGAQHEN VPFIAVTSFL CLRFFSPAIM 480
SPKLFHLRER HADARTSRTL LLLAKAVQNV GNMDTPASRA KEAWMEPLQP TVRQGVAQLK 540
DFITKLVDIE EKDELDLQRT LSLQAPPVKE GPLFIHRTKG KGPLMSSSFK KLYFSLTTEA 600
LSFAKTPSSK KSALIKLANI RAAEKVEEKS FGGSHVMQVI YTDDAGRPQT AYLQCKCVNE 660
LNQWLSALRK VSINNTGLLG SYHPGVFRGD KWSCCHQKEK TGQGCDKTRS RVTLQEWNDP 720
LDHDLEAQLI YRHLLGVEAM LWERHRELSG GAEAGTVPTS PGKVPEDSLA RLLRVLQDLR 780
EAHSSSPAGS PPSEPNCLLE LQT
804Fasta Sequence
>O43374|RASA4|Homo sapiens(Human)
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
|
| Keyword |
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0343--GTPase activation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR000008--C2_dom
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR023152--RasGAP_CS
IPR001936--RasGAP_dom
IPR008936--Rho_GTPase_activation_prot
IPR001562--Znf_Btk_motif
|
| PROSITE |
PS50004--C2
PS50003--PH_DOMAIN
PS00509--RAS_GTPASE_ACTIV_1
PS50018--RAS_GTPASE_ACTIV_2
PS51113--ZF_BTK
|
| Pfam |
PF00779--BTK
PF00168--C2
PF00169--PH
PF00616--RasGAP
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031235--C:intrinsic component of the cytoplasmic side of the plasma membrane
GO:0005096--F:GTPase activator activity
GO:0046872--F:metal ion binding
GO:0000186--P:activation of MAPKK activity
GO:0007411--P:axon guidance
GO:0071277--P:cellular response to calcium ion
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0034260--P:negative regulation of GTPase activity
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0043547--P:positive regulation of GTPase activity
GO:0007265--P:Ras protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
|
