dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001524
Uniprot Accession O43365; HXA3_HUMAN; A4D181;
Genbank Protein ID NP_109377.1; NP_705895.1; XP_005249787.1; XP_005249788.1; XP_005249789.1; XP_006715778.1; XP_011513645.1;
Genbank Nucleotide ID NM_030661.4; NM_153631.2; XM_005249730.2; XM_005249731.2; XM_005249732.3; XM_006715715.2; XM_011515343.1;
Protein Name Homeobox protein Hox-A3
Protein Synonyms/Alias Homeobox protein Hox-1E;
Gene Name HOXA3
Gene Synonyms/Alias HOX1E;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Phosphorylation Sites
dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
143TPANAAKSPLLNSPTdbPTM 3.0;PhosphoSitePlus;curated20363803; 16381945; 23193290; 22135298; 25850435; 25627689
148AKSPLLNSPTVAKQIdbPTM 3.0;PhosphoSitePlus;curated20363803; 16381945; 23193290; 22135298; 25850435; 25627689;
150SPLLNSPTVAKQIFPcurated25627689
184ESCAGDKSPPGQASScurated23898821
196ASSKRARTAYTSAQLPhosphoSitePlus22135298
263LTSSGGQSPSRSPVPPhosphoSitePlus;curated22135298; 25850435
Sequence
(Fasta)
MQKATYYDSS AIYGGYPYQA ANGFAYNANQ QPYPASAALG ADGEYHRPAC SLQSPSSAGG 60
HPKAHELSEA CLRTLSAPPS QPPSLGEPPL HPPPPQAAPP APQPPQPAPQ PPAPTPAAPP 120
PPSSASPPQN ASNNPTPANA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SSSSSGESCA 180
GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ 240
NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGAGGYLNSM HSLVNSVPYE PQSPPPFSKP 300
PQGTYGLPPA SYPASLPSCA PPPPPQKRYT AAGAGAGGTP DYDPHAHGLQ GNGSYGTPHI 360
QGSPVFVGGS YVEPMSNSGP ALFGLTHLPH AASGAMDYGG AGPLGSGHHH GPGPGEPHPT 420
YTDLTGHHPS QGRIQEAPKL THL 444
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR025281--DUF4074
IPR001827--Homeobox_Antennapedia_CS
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR020479--Homeobox_metazoa
IPR009057--Homeodomain-like

PROSITE

PS00032--ANTENNAPEDIA
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2

Pfam

PF13293--DUF4074
PF00046--Homeobox

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001525--P:angiogenesis
GO:0009952--P:anterior/posterior pattern specification
GO:0001974--P:blood vessel remodeling
GO:0051216--P:cartilage development
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0021615--P:glossopharyngeal nerve morphogenesis
GO:0048645--P:organ formation
GO:0060017--P:parathyroid gland development
GO:0008284--P:positive regulation of cell proliferation
GO:0010159--P:specification of organ position
GO:0048538--P:thymus development
GO:0030878--P:thyroid gland development
GO:0006351--P:transcription, DNA-templated