dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001520
Uniprot Accession O43347; MSI1H_HUMAN; Q96PU0; Q96PU1; Q96PU2; Q96PU3;
Genbank Protein ID NP_002433.1; XP_011536663.1;
Genbank Nucleotide ID NM_002442.3; XM_011538361.1;
Protein Name RNA-binding protein Musashi homolog 1
Protein Synonyms/Alias
Gene Name MSI1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
12APQPGLASPDSPHDPdbPTM 3.0;HPRD 9;PhosphoSitePlus19413330; 16381945; 23193290; 18988627; 22135298
145AMLMFDKTTNRHRGFHPRD 9;curated20068231; 18988627
191AQPKEVMSPTGSARGdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated19413330; 16381945; 23193290; 19664995; 21406692; 18988627;
193PKEVMSPTGSARGRScurated22817900
251PEFRVERTPLPSAPVPhosphoSitePlus22135298
255VERTPLPSAPVLPELPhosphoSitePlus22135298
312GGFLGTTSPGPMAELPhosphoSitePlus22135298
Sequence
(Fasta)		METDAPQPGL ASPDSPHDPC KMFIGGLSWQ TTQEGLREYF GQFGEVKECL VMRDPLTKRS 60
RGFGFVTFMD QAGVDKVLAQ SRHELDSKTI DPKVAFPRRA QPKMVTRTKK IFVGGLSVNT 120
TVEDVKQYFE QFGKVDDAML MFDKTTNRHR GFGFVTFESE DIVEKVCEIH FHEINNKMVE 180
CKKAQPKEVM SPTGSARGRS RVMPYGMDAF MLGIGMLGYP GFQATTYASR SYTGLAPGYT 240
YQFPEFRVER TPLPSAPVLP ELTAIPLTAY GPMAAAAAAA AVVRGTGSHP WTMAPPPGST 300
PSRTGGFLGT TSPGPMAELY GAANQDSGVS SYISAASPAP STGFGHSLGG PLIATAFTNG 360
YH 363
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
Interpro

IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
PROSITE

PS50102--RRM
Pfam

PF00076--RRM_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005844--C:polysome
GO:0000166--F:nucleotide binding
GO:0044822--F:poly(A) RNA binding
GO:0008266--F:poly(U) RNA binding
GO:0003723--F:RNA binding
GO:0007399--P:nervous system development