dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001517
Uniprot Accession O43320; FGF16_HUMAN;
Genbank Protein ID NP_003859.1;
Genbank Nucleotide ID NM_003868.2;
Protein Name Fibroblast growth factor 16
Protein Synonyms/Alias
Gene Name FGF16
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
111ISIRGVDSGLYLGMNdbPTM 3.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 22135298
114RGVDSGLYLGMNERGdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298
184TKRHQKFTHFLPRPVcurated22817900
Sequence
(Fasta)
MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL 60
RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER 120
GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH 180
QKFTHFLPRP VDPSKLPSMS RDLFHYR 208
Keyword

KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0325--Glycoprotein
KW-0339--Growth factor
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0964--Secreted

Interpro

IPR008996--Cytokine_IL1-like
IPR028285--FGF16
IPR002209--Fibroblast_GF_fam
IPR028142--IL-1_fam/FGF_fam

PROSITE

PS00247--HBGF_FGF

Pfam

PF00167--FGF

Gene Ontology

GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005622--C:intracellular
GO:0008083--F:growth factor activity
GO:0000186--P:activation of MAPKK activity
GO:0007411--P:axon guidance
GO:0007267--P:cell-cell signaling
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0008152--P:metabolic process
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0009887--P:organ morphogenesis
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0070349--P:positive regulation of brown fat cell proliferation
GO:2000546--P:positive regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:0007265--P:Ras protein signal transduction
GO:0009266--P:response to temperature stimulus
GO:0007165--P:signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway