| Tag |
Content |
| dbPAF ID |
dbPAF-0001515 |
| Uniprot Accession |
O43316; PAX4_HUMAN; O95161; Q6B0H0;
|
| Genbank Protein ID |
NP_006184.2;
|
| Genbank Nucleotide ID |
NM_006193.2;
|
| Protein Name |
Paired box protein Pax-4 |
| Protein Synonyms/Alias |
|
| Gene Name |
PAX4 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.Functional Description
Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MHQDGISSMN QLGGLFVNGR PLPLDTRQQI VRLAVSGMRP CDISRILKVS NGCVSKILGR 60
YYRTGVLEPK GIGGSKPRLA TPPVVARIAQ LKGECPALFA WEIQRQLCAE GLCTQDKTPS 120
VSSINRVLRA LQEDQGLPCT RLRSPAVLAP AVLTPHSGSE TPRGTHPGTG HRNRTIFSPS 180
QAEALEKEFQ RGQYPDSVAR GKLATATSLP EDTVRVWFSN RRAKWRRQEK LKWEMQLPGA 240
SQGLTVPRVA PGIISAQQSP GSVPTAALPA LEPLGPSCYQ LCWATAPERC LSDTPPKACL 300
KPCWDCGSFL LPVIAPSCVD VAWPCLDASL AHHLIGGAGK ATPTHFSHWP
351Fasta Sequence
>O43316|PAX4|Homo sapiens(Human)
MHQDGISSMNQLGGLFVNGRPLPLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLRALQEDQGLPCTRLRSPAVLAPAVLTPHSGSETPRGTHPGTGHRNRTIFSPSQAEALEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGLTVPRVAPGIISAQQSPGSVPTAALPALEPLGPSCYQLCWATAPERCLSDTPPKACLKPCWDCGSFLLPVIAPSCVDVAWPCLDASLAHHLIGGAGKATPTHFSHWP
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0219--Diabetes mellitus
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-0563--Paired box
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR009057--Homeodomain-like
IPR001523--Paired_dom
IPR011991--WHTH_DNA-bd_dom
|
| PROSITE |
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
PS00034--PAIRED_1
PS51057--PAIRED_2
|
| Pfam |
PF00046--Homeobox
PF00292--PAX
|
| Gene Ontology |
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0030154--P:cell differentiation
GO:0007623--P:circadian rhythm
GO:0031018--P:endocrine pancreas development
GO:0043066--P:negative regulation of apoptotic process
GO:0009887--P:organ morphogenesis
GO:0045597--P:positive regulation of cell differentiation
GO:0051591--P:response to cAMP
GO:0042493--P:response to drug
GO:0060041--P:retina development in camera-type eye
GO:0006351--P:transcription, DNA-templated
|
