dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001514
Uniprot Accession O43315; AQP9_HUMAN; Q9NP32;
Genbank Protein ID NP_066190.2;
Genbank Nucleotide ID NM_020980.3;
Protein Name Aquaporin-9
Protein Synonyms/Alias
Gene Name AQP9
Gene Synonyms/Alias SSC1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
11EGAEKGKSFKQRLVLdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated17346701; 16381945; 23193290; 21873454; 22135298; 22817900
222MNPARDLSPRLFTALdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 17346701; 18988627; 21081558;
Sequence
(Fasta)		MQPEGAEKGK SFKQRLVLKS SLAKETLSEF LGTFILIVLG CGCVAQAILS RGRFGGVITI 60
NVGFSMAVAM AIYVAGGVSG GHINPAVSLA MCLFGRMKWF KLPFYVGAQF LGAFVGAATV 120
FGIYYDGLMS FAGGKLLIVG ENATAHIFAT YPAPYLSLAN AFADQVVATM ILLIIVFAIF 180
DSRNLGAPRG LEPIAIGLLI IVIASSLGLN SGCAMNPARD LSPRLFTALA GWGFEVFRAG 240
NNFWWIPVVG PLVGAVIGGL IYVLVIEIHH PEPDSVFKTE QSEDKPEKYE LSVIM 296
Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR023271--Aquaporin-like
IPR015685--Aquaporin_9
IPR000425--MIP
IPR022357--MIP_CS
PROSITE

PS00221--MIP
Pfam

PF00230--MIP
Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005886--C:plasma membrane
GO:0005275--F:amine transmembrane transporter activity
GO:0046943--F:carboxylic acid transmembrane transporter activity
GO:0015254--F:glycerol channel activity
GO:0015166--F:polyol transmembrane transporter activity
GO:0015288--F:porin activity
GO:0005345--F:purine nucleobase transmembrane transporter activity
GO:0005350--F:pyrimidine nucleobase transmembrane transporter activity
GO:0015204--F:urea transmembrane transporter activity
GO:0015250--F:water channel activity
GO:0005372--F:water transmembrane transporter activity
GO:0015837--P:amine transport
GO:0015722--P:canalicular bile acid transport
GO:0046942--P:carboxylic acid transport
GO:0071320--P:cellular response to cAMP
GO:0009992--P:cellular water homeostasis
GO:0007588--P:excretion
GO:0015793--P:glycerol transport
GO:0006955--P:immune response
GO:0034220--P:ion transmembrane transport
GO:0008152--P:metabolic process
GO:0015791--P:polyol transport
GO:0006863--P:purine nucleobase transport
GO:0015855--P:pyrimidine nucleobase transport
GO:0072531--P:pyrimidine-containing compound transmembrane transport
GO:0046689--P:response to mercury ion
GO:0010033--P:response to organic substance
GO:0006970--P:response to osmotic stress
GO:0055085--P:transmembrane transport
GO:0006810--P:transport
GO:0071918--P:urea transmembrane transport
GO:0030104--P:water homeostasis
GO:0006833--P:water transport