dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001512
Uniprot Accession O43313; ATMIN_HUMAN; A8K4H8; Q68DC9;
Genbank Protein ID NP_001287657.1; NP_056066.2;
Genbank Nucleotide ID NM_001300728.1; NM_015251.2;
Protein Name ATM interactor
Protein Synonyms/Alias ATM/ATR-substrate CHK2-interacting zinc finger protein;ASCIZ;Zinc finger protein 822;
Gene Name ATMIN
Gene Synonyms/Alias KIAA0431;ZNF822;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
270SEIKLEPSFEDSCGSPhosphoSitePlus22135298
391VQVNFGKSPSNPLQEcurated25627689
Sequence
(Fasta)		MAASEAAAAA GSAALAAGAR AVPAATTGAA AAASGPWVPP GPRLRGSRPR PAGATQQPAV 60
PAPPAGELIQ PSVSELSRAV RTNILCTVRG CGKILPNSPA LNMHLVKSHR LQDGIVNPTI 120
RKDLKTGPKF YCCPIEGCPR GPERPFSQFS LVKQHFMKMH AEKKHKCSKC SNSYGTEWDL 180
KRHAEDCGKT FRCTCGCPYA SRTALQSHIY RTGHEIPAEH RDPPSKKRKM ENCAQNQKLS 240
NKTIESLNNQ PIPRPDTQEL EASEIKLEPS FEDSCGSNTD KQTLTTPPRY PQKLLLPKPK 300
VALVKLPVMQ FSVMPVFVPT ADSSAQPVVL GVDQGSATGA VHLMPLSVGT LILGLDSEAC 360
SLKESLPLFK IANPIAGEPI STGVQVNFGK SPSNPLQELG NTCQKNSISS INVQTDLSYA 420
SQNFIPSAQW ATADSSVSSC SQTDLSFDSQ VSLPISVHTQ TFLPSSKVTS SIAAQTDAFM 480
DTCFQSGGVS RETQTSGIES PTDDHVQMDQ AGMCGDIFES VHSSYNVATG NIISNSLVAE 540
TVTHSLLPQN EPKTLNQDIE KSAPIINFSA QNSMLPSQNM TDNQTQTIDL LSDLENILSS 600
NLPAQTLDHR SLLSDTNPGP DTQLPSGPAQ NPGIDFDIEE FFSASNIQTQ TEESELSTMT 660
TEPVLESLDI ETQTDFLLAD TSAQSYGCRG NSNFLGLEMF DTQTQTDLNF FLDSSPHLPL 720
GSILKHSSFS VSTDSSDTET QTEGVSTAKN IPALESKVQL NSTETQTMSS GFETLGSLFF 780
TSNETQTAMD DFLLADLAWN TMESQFSSVE TQTSAEPHTV SNF 824
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
PROSITE

PS00028--ZINC_FINGER_C2H2_1
Pfam
Gene Ontology

GO:0005634--C:nucleus
GO:0045502--F:dynein binding
GO:0046872--F:metal ion binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0060271--P:cilium morphogenesis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated