dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001511
Uniprot Accession O43312; MTSS1_HUMAN; J3KNK6; Q8TCA2; Q96RX2;
Genbank Protein ID NP_001269900.1; NP_001269903.1; NP_055566.3; XP_011515710.1;
Genbank Nucleotide ID NM_001282971.1; NM_001282974.1; NM_014751.5; XM_011517408.1;
Protein Name Metastasis suppressor protein 1
Protein Synonyms/Alias Metastasis suppressor YGL-1;Missing in metastasis protein;
Gene Name MTSS1
Gene Synonyms/Alias KIAA0429;MIM;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
Phosphorylation Sites
dbPAF PTMs: 36 (View all)
PositionPeptidesSourceReferences ( PMIDs )
144IKKKSSDTLKLQKKAPhosphoSitePlus;curated22135298; 25003641; 25849741
255KGSDYSWSYQTPPSSPhosphoSitePlus;curated22135298; 23403867; 23663014
256GSDYSWSYQTPPSSPPhosphoSitePlus;curated22135298; 23090842
258DYSWSYQTPPSSPSTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18088087; 16381945; 23193290; 22115753; 18988627; 22135298;
261WSYQTPPSSPSTTMSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18088087; 16381945; 23193290; 22115753; 18988627; 22135298;
262SYQTPPSSPSTTMSRdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298; 23403867; 23090842
264QTPPSSPSTTMSRKScurated23090842
265TPPSSPSTTMSRKSSPhosphoSitePlus;curated22135298; 22817900
266PPSSPSTTMSRKSSVPhosphoSitePlus22135298
268SSPSTTMSRKSSVCScurated22115753
271STTMSRKSSVCSSLNcurated22115753; 22798277
272TTMSRKSSVCSSLNSdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298; 22798277; 25849741
275SRKSSVCSSLNSVNSPhosphoSitePlus;curated22135298; 23090842
276RKSSVCSSLNSVNSScurated23911959; 22115753
294SSGSHSHSPSSHYRYdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298
315QQAPVRLSSVSSHDSPhosphoPep 2.0;curated19060867; 24972180
316QAPVRLSSVSSHDSGPhosphoPep 2.0;curated19060867; 22115753
318PVRLSSVSSHDSGFIcurated22115753
322SSVSSHDSGFISQDAPhosphoSitePlus22135298
383SRLLPRVTSVHLPDYcurated22115753
Sequence
(Fasta)
MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA AAAFLDAFQK 60
VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL IDCLINPLQE QMEEWKKVAN 120
QLDKDHAKEY KKARQEIKKK SSDTLKLQKK AKKGRGDIQP QLDSALQDVN DKYLLLEETE 180
KQAVRKALIE ERGRFCTFIS MLRPVIEEEI SMLGEITHLQ TISEDLKSLT MDPHKLPSSS 240
EQVILDLKGS DYSWSYQTPP SSPSTTMSRK SSVCSSLNSV NSSDSRSSGS HSHSPSSHYR 300
YRSSNLAQQA PVRLSSVSSH DSGFISQDAF QSKSPSPMPP EAPNQLSNGF SHYSLSSESH 360
VGPTGAGLFP HCLPASRLLP RVTSVHLPDY AHYYTIGPGM FPSSQIPSWK DWAKPGPYDQ 420
PLVNTLQRRK EKREPDPNGG GPTTASGPPA AAEEAQRPRS MTVSAATRPG EEMEACEELA 480
LALSRGLQLD TQRSSRDSLQ CSSGYSTQTT TPCCSEDTIP SQVSDYDYFS VSGDQEADQQ 540
EFDKSSTIPR NSDISQSYRR MFQAKRPAST AGLPTTLGPA MVTPGVATIR RTPSTKPSVR 600
RGTIGAGPIP IKTPVIPVKT PTVPDLPGVL PAPPDGPEER GEHSPESPSV GEGPQGVTSM 660
PSSMWSGQAS VNPPLPGPKP SIPEEHRQAI PESEAEDQER EPPSATVSPG QIPESDPADL 720
SPRDTPQGED MLNAIRRGVK LKKTTTNDRS APRFS 756
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0043--Tumor suppressor

Interpro

IPR013606--I-BAR_dom
IPR027682--MIM
IPR030127--MIM/ABBA
IPR003124--WH2_dom

PROSITE

PS51338--IMD
PS51082--WH2

Pfam

PF08397--IMD
PF02205--WH2

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005912--C:adherens junction
GO:0005737--C:cytoplasm
GO:0030139--C:endocytic vesicle
GO:0001726--C:ruffle
GO:0003785--F:actin monomer binding
GO:0042802--F:identical protein binding
GO:0005102--F:receptor binding
GO:0030036--P:actin cytoskeleton organization
GO:0030041--P:actin filament polymerization
GO:0034334--P:adherens junction maintenance
GO:0030282--P:bone mineralization
GO:0007155--P:cell adhesion
GO:0071498--P:cellular response to fluid shear stress
GO:2001013--P:epithelial cell proliferation involved in renal tubule morphogenesis
GO:0072102--P:glomerulus morphogenesis
GO:0001701--P:in utero embryonic development
GO:0010960--P:magnesium ion homeostasis
GO:0030035--P:microspike assembly
GO:0006928--P:movement of cell or subcellular component
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0072160--P:nephron tubule epithelial cell differentiation
GO:0007009--P:plasma membrane organization
GO:0032233--P:positive regulation of actin filament bundle assembly
GO:0002230--P:positive regulation of defense response to virus by host
GO:0061333--P:renal tubule morphogenesis
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0098792--P:xenophagy