dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001510
Uniprot Accession O43310; CTIF_HUMAN; B3KTR8; Q8IVD5;
Genbank Protein ID NP_001135869.1; NP_055587.1; XP_006722650.1; XP_006722651.1; XP_006722652.1; XP_011524581.1;
Genbank Nucleotide ID NM_001142397.1; NM_014772.2; XM_006722587.2; XM_006722588.2; XM_006722589.2; XM_011526279.1;
Protein Name CBP80/20-dependent translation initiation factor
Protein Synonyms/Alias
Gene Name CTIF
Gene Synonyms/Alias KIAA0427;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
4----MENSSAASASScurated23090842
5---MENSSAASASSEcurated23090842
8MENSSAASASSEAGScurated23090842
10NSSAASASSEAGSSRPhosphoSitePlus22135298
11SSAASASSEAGSSRScurated23090842
16ASSEAGSSRSQEIEEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19413330; 16381945; 23193290; 18988627; 22135298; 23090842
18SEAGSSRSQEIEELEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 19413330; 16381945; 23193290; 21659604; 18988627;
72CSEPLDSSCSFSRGRcurated23186163
285ENPKLEDTAGDTGHSPhosphoSitePlus;curated22135298; 23403867
289LEDTAGDTGHSSLEAPhosphoSitePlus;UniProt22135298; 24275569
292TAGDTGHSSLEAPRSPhosphoSitePlus22135298
299SSLEAPRSPDTLAPVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18088087; 16381945; 23193290; 19664994; 20166139; 18988627;
302EAPRSPDTLAPVASEPhosphoSitePlus;curated22135298; 23186163
328VETKRKDSILPERIGPhosphoSitePlus;curated22135298; 25003641; 21857030; 24961811
364KDEVAVETTTPQQNKcurated25627689
365DEVAVETTTPQQNKMcurated25627689
366EVAVETTTPQQNKMDcurated25627689
Sequence
(Fasta)		MENSSAASAS SEAGSSRSQE IEELERFIDS YVLEYQVQGL LADKTEGDGE SERTQSHISQ 60
WTADCSEPLD SSCSFSRGRA PPQQNGSKDN SLDMLGTDIW AANTFDSFSG ATWDLQPEKL 120
DFTQFHRKVR HTPKQPLPHI DREGCGKGKL EDGDGINLND IEKVLPAWQG YHPMPHEVEI 180
AHTKKLFRRR RNDRRRQQRP PGGNKPQQHG DHQPGSAKHN RDHQKSYQGG SAPHPSGRPT 240
HHGYSQNRRW HHGNMKHPPG DKGEAGAHRN AKETMTIENP KLEDTAGDTG HSSLEAPRSP 300
DTLAPVASER LPPQQSGGPE VETKRKDSIL PERIGERPKI TLLQSSKDRL RRRLKEKDEV 360
AVETTTPQQN KMDKLIEILN SMRNNSSDVD TKLTTFMEEA QNSTNSEEML GEIVRTIYQK 420
AVSDRSFAFT AAKLCDKMAL FMVEGTKFRS LLLNMLQKDF TVREELQQQD VERWLGFITF 480
LCEVFGTMRS STGEPFRVLV CPIYTCLREL LQSQDVKEDA VLCCSMELQS TGRLLEEQLP 540
EMMTELLASA RDKMLCPSES MLTRSLLLEV IELHANSWNP LTPPITQYYN RTIQKLTA 599
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0866--Nonsense-mediated mRNA decay
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0810--Translation regulation
Interpro

IPR016024--ARM-type_fold
IPR016021--MIF4-like
IPR003890--MIF4G-like_typ-3
PROSITE
Pfam

PF02854--MIF4G
Gene Ontology

GO:0005737--C:cytoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0003723--F:RNA binding
GO:0000184--P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006446--P:regulation of translational initiation