| Tag |
Content |
| dbPAF ID |
dbPAF-0001508 |
| Uniprot Accession |
O43307; ARHG9_HUMAN; A8K1S8; B4DHC7; F8W7P8; Q5JSL6;
|
| Genbank Protein ID |
NP_001166950.1; NP_001166951.1; NP_056000.1;
|
| Genbank Nucleotide ID |
NM_001173479.1; NM_001173480.1; NM_015185.2;
|
| Protein Name |
Rho guanine nucleotide exchange factor 9 |
| Protein Synonyms/Alias |
Collybistin;PEM-2 homolog;Rac/Cdc42 guanine nucleotide exchange factor 9; |
| Gene Name |
ARHGEF9 |
| Gene Synonyms/Alias |
ARHDH9;KIAA0424; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.Functional Description
Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MTLLITGDSI VSAEAVWDHV TMANRELAFK AGDVIKVLDA SNKDWWWGQI DDEEGWFPAS 60
FVRLWVNQED EVEEGPSDVQ NGHLDPNSDC LCLGRPLQNR DQMRANVINE IMSTERHYIK 120
HLKDICEGYL KQCRKRRDMF SDEQLKVIFG NIEDIYRFQM GFVRDLEKQY NNDDPHLSEI 180
GPCFLEHQDG FWIYSEYCNN HLDACMELSK LMKDSRYQHF FEACRLLQQM IDIAIDGFLL 240
TPVQKICKYP LQLAELLKYT AQDHSDYRYV AAALAVMRNV TQQINERKRR LENIDKIAQW 300
QASVLDWEGE DILDRSSELI YTGEMAWIYQ PYGRNQQRVF FLFDHQMVLC KKDLIRRDIL 360
YYKGRIDMDK YEVVDIEDGR DDDFNVSMKN AFKLHNKETE EIHLFFAKKL EEKIRWLRAF 420
REERKMVQED EKIGFEISEN QKRQAAMTVR KVPKQKGVNS ARSVPPSYPP PQDPLNHGQY 480
LVPDGIAQSQ VFEFTEPKRS QSPFWQNFSR LTPFKK
517Fasta Sequence
>O43307|ARHGEF9|Homo sapiens(Human)
MTLLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0887--Epilepsy
KW-0344--Guanine-nucleotide releasing factor
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
|
| Interpro |
IPR000219--DH-domain
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR001452--SH3_domain
|
| PROSITE |
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3
|
| Pfam |
PF00169--PH
PF00621--RhoGEF
PF00018--SH3_1
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0097190--P:apoptotic signaling pathway
GO:0034220--P:ion transmembrane transport
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0007268--P:synaptic transmission
GO:0055085--P:transmembrane transport
|
