| Tag |
Content |
| dbPAF ID |
dbPAF-0001507 |
| Uniprot Accession |
O43306; ADCY6_HUMAN; Q9NR75; Q9UDB0;
|
| Genbank Protein ID |
NP_056085.1; XP_006719273.1;
|
| Genbank Nucleotide ID |
NM_015270.4; XM_006719210.2;
|
| Protein Name |
Adenylate cyclase type 6 |
| Protein Synonyms/Alias |
ATP pyrophosphate-lyase 6;Adenylate cyclase type VI;Adenylyl cyclase 6;Ca(2+)-inhibitable adenylyl cyclase; |
| Gene Name |
ADCY6 |
| Gene Synonyms/Alias |
KIAA0422; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity).Functional Description
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 10 |
Sequence
(Fasta) | MSWFSGLLVP KVDERKTAWG ERNGQKRSRR RGTRAGGFCT PRYMSCLRDA EPPSPTPAGP 60
PRCPWQDDAF IRRGGPGKGK ELGLRAVALG FEDTEVTTTA GGTAEVAPDA VPRSGRSCWR 120
RLVQVFQSKQ FRSAKLERLY QRYFFQMNQS SLTLLMAVLV LLTAVLLAFH AAPARPQPAY 180
VALLACAAAL FVGLMVVCNR HSFRQDSMWV VSYVVLGILA AVQVGGALAA DPRSPSAGLW 240
CPVFFVYIAY TLLPIRMRAA VLSGLGLSTL HLILAWQLNR GDAFLWKQLG ANVLLFLCTN 300
VIGICTHYPA EVSQRQAFQE TRGYIQARLH LQHENRQQER LLLSVLPQHV AMEMKEDINT 360
KKEDMMFHKI YIQKHDNVSI LFADIEGFTS LASQCTAQEL VMTLNELFAR FDKLAAENHC 420
LRIKILGDCY YCVSGLPEAR ADHAHCCVEM GVDMIEAISL VREVTGVNVN MRVGIHSGRV 480
HCGVLGLRKW QFDVWSNDVT LANHMEAGGR AGRIHITRAT LQYLNGDYEV EPGRGGERNA 540
YLKEQHIETF LILGASQKRK EEKAMLAKLQ RTRANSMEGL MPRWVPDRAF SRTKDSKAFR 600
QMGIDDSSKD NRGTQDALNP EDEVDEFLSR AIDARSIDQL RKDHVRRFLL TFQREDLEKK 660
YSRKVDPRFG AYVACALLVF CFICFIQLLI FPHSTLMLGI YASIFLLLLI TVLICAVYSC 720
GSLFPKALQR LSRSIVRSRA HSTAVGIFSV LLVFTSAIAN MFTCNHTPIR SCAARMLNLT 780
PADITACHLQ QLNYSLGLDA PLCEGTMPTC SFPEYFIGNM LLSLLASSVF LHISSIGKLA 840
MIFVLGLIYL VLLLLGPPAT IFDNYDLLLG VHGLASSNET FDGLDCPAAG RVALKYMTPV 900
ILLVFALALY LHAQQVESTA RLDFLWKLQA TGEKEEMEEL QAYNRRLLHN ILPKDVAAHF 960
LARERRNDEL YYQSCECVAV MFASIANFSE FYVELEANNE GVECLRLLNE IIADFDEIIS 1020
EERFRQLEKI KTIGSTYMAA SGLNASTYDQ VGRSHITALA DYAMRLMEQM KHINEHSFNN 1080
FQMKIGLNMG PVVAGVIGAR KPQYDIWGNT VNVSSRMDST GVPDRIQVTT DLYQVLAAKG 1140
YQLECRGVVK VKGKGEMTTY FLNGGPSS
1169Fasta Sequence
>O43306|ADCY6|Homo sapiens(Human)
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
|
| Keyword |
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0115--cAMP biosynthesis
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0969--Cilium
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0325--Glycoprotein
KW-0456--Lyase
KW-0460--Magnesium
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR001054--A/G_cyclase
IPR018297--A/G_cyclase_CS
IPR032628--AC_N
IPR030672--Adcy
IPR009398--Adcy_conserved_dom
IPR029787--Nucleotide_cyclase
|
| PROSITE |
PS00452--GUANYLATE_CYCLASE_1
PS50125--GUANYLATE_CYCLASE_2
|
| Pfam |
PF16214--AC_N
PF06327--DUF1053
PF00211--Guanylate_cyc
|
| Gene Ontology |
GO:0005929--C:cilium
GO:0016021--C:integral component of membrane
GO:0005622--C:intracellular
GO:0031226--C:intrinsic component of plasma membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0004016--F:adenylate cyclase activity
GO:0005524--F:ATP binding
GO:0008294--F:calcium- and calmodulin-responsive adenylate cyclase activity
GO:0046872--F:metal ion binding
GO:0019901--F:protein kinase binding
GO:0007202--P:activation of phospholipase C activity
GO:0034199--P:activation of protein kinase A activity
GO:0007189--P:adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193--P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0006171--P:cAMP biosynthetic process
GO:0019933--P:cAMP-mediated signaling
GO:0071870--P:cellular response to catecholamine stimulus
GO:1904322--P:cellular response to forskolin
GO:0071377--P:cellular response to glucagon stimulus
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:1904117--P:cellular response to vasopressin
GO:0007212--P:dopamine receptor signaling pathway
GO:0006112--P:energy reserve metabolic process
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0010977--P:negative regulation of neuron projection development
GO:0035811--P:negative regulation of urine volume
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0042312--P:regulation of vasodilation
GO:0003091--P:renal water homeostasis
GO:0007165--P:signal transduction
GO:0044281--P:small molecule metabolic process
GO:0007268--P:synaptic transmission
GO:0055085--P:transmembrane transport
GO:0006833--P:water transport
|
