dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001505
Uniprot Accession O43303; CP110_HUMAN; B7WP23; O43335; Q68DV9; Q8NE13;
Genbank Protein ID NP_001185951.1; NP_055526.3; XP_005255776.1; XP_011544293.1; XP_011544294.1;
Genbank Nucleotide ID NM_001199022.1; NM_014711.4; XM_005255719.1; XM_011545991.1; XM_011545992.1;
Protein Name Centriolar coiled-coil protein of 110 kDa
Protein Synonyms/Alias Centrosomal protein of 110 kDa;CP110;Cep110;
Gene Name CCP110
Gene Synonyms/Alias CEP110;CP110;KIAA0419;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
Phosphorylation Sites
 dbPAF PTMs: 32 (View all)
PositionPeptidesSourceReferences ( PMIDs )
45FHGVAILSPLLNIEKdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated12361598; 16381945; 23193290; 18988627; 22135298; 25627689;
107FDQWEMETVYSNSEVPhosphoSitePlus22135298
109QWEMETVYSNSEVRNPhosphoSitePlus;curated22135298; 22817900
165GIDLARDSEGFNSPKPhosphoSitePlus;curated22135298; 25627689
170RDSEGFNSPKQCDSSdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20363803; 22115753; 16381945; 23193290; 12361598; 18988627;
194FPKTSSATPQETLISdbPTM 3.0;HPRD 9;PhosphoSitePlus12361598; 16381945; 23193290; 18988627; 22135298
247EREQSRRSLRGSINRPhosphoSitePlus22135298
251SRRSLRGSINRIVNEPhosphoSitePlus22135298
259INRIVNESHLDKEHDPhosphoSitePlus22135298
366GSYAKLPSPEPSMSPdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19413330; 16381945; 23193290; 20363803; 12361598; 18988627;
370KLPSPEPSMSPKMHRdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19369195; 19413330; 16381945; 23193290; 18988627; 22135298;
372PSPEPSMSPKMHRRRdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated19413330; 19690332; 16381945; 23193290; 20363803; 22115753;
380PKMHRRRSRTSSACHPhosphoSitePlus22135298
382MHRRRSRTSSACHILPhosphoSitePlus;curated22135298; 23898821
383HRRRSRTSSACHILIPhosphoSitePlus22135298
384RRRSRTSSACHILINPhosphoSitePlus;curated22135298; 23898821
400PINACELSPKGKEQAdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated12361598; 16381945; 23193290; 18988627; 22135298; 23917254;
441GVCSSKVYVGKNTSEPhosphoSitePlus22135298
446KVYVGKNTSEVKEDVcurated22817900
508MPKLHEPYASSQCIAPhosphoSitePlus22135298
Sequence
(Fasta)		MEEYEKFCEK SLARIQEASL STESFLPAQS ESISLIRFHG VAILSPLLNI EKRKEMQQEK 60
QKALDVEARK QVNRKKALLT RVQEILDNVQ VRKAPNASDF DQWEMETVYS NSEVRNLNVP 120
ATFPNSFPSH TEHSTAAKLD KIAGILPLDN EDQCKTDGID LARDSEGFNS PKQCDSSNIS 180
HVENEAFPKT SSATPQETLI SDGPFSVNEQ QDLPLLAEVI PDPYVMSLQN LMKKSKEYIE 240
REQSRRSLRG SINRIVNESH LDKEHDAVEV ADCVKEKGQL TGKHCVSVIP DKPSLNKSNV 300
LLQGASTQAS SMSMPVLASF SKVDIPIRTG HPTVLESNSD FKVIPTFVTE NNVIKSLTGS 360
YAKLPSPEPS MSPKMHRRRS RTSSACHILI NNPINACELS PKGKEQAMDL IIQDTDENTN 420
VPEIMPKLPT DLAGVCSSKV YVGKNTSEVK EDVVLGKSNQ VCQSSGNHLE NKVTHGLVTV 480
EGQLTSDERG AHIMNSTCAA MPKLHEPYAS SQCIASPNFG TVSGLKPASM LEKNCSLQTE 540
LNKSYDVKNP SPLLMQNQNT RQQMDTPMVS CGNEQFLDNS FEKVKRRLDL DIDGLQKENC 600
PYVITSGITE QERQHLPEKR YPKGSGFVNK NKMLGTSSKE SEELLKSKML AFEEMRKRLE 660
EQHAQQLSLL IAEQEREQER LQKEIEEQEK MLKEKKAMTA EASELDINNA VELEWRKISD 720
SSLLETMLSQ ADSLHTSNSN SSGFTNSAMQ YSFVSANEAP FYLWGSSTSG LTKLSVTRPF 780
GRAKTRWSQV FSLEIQAKFN KITAVAKGFL TRRLMQTDKL KQLRQTVKDT MEFIRSFQSE 840
APLKRGIVSA QDASLQERVL AQLRAALYGI HDIFFVMDAA ERMSILHHDR EVRKEKMLRQ 900
MDKMKSPRVA LSAATQKSLD RKKYMKAAEM GMPNKKFLVK QNPSETRVLQ PNQGQNAPVH 960
RLLSRQGTPK TSVKGVVQNR QKPSQSRVPN RVPVSGVYAG KIQRKRPNVA TI 1013
Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro
PROSITE
Pfam
Gene Ontology

GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0043234--C:protein complex
GO:0030030--P:cell projection organization
GO:0007099--P:centriole replication
GO:0051298--P:centrosome duplication
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0000278--P:mitotic cell cycle
GO:0006996--P:organelle organization
GO:0032465--P:regulation of cytokinesis