dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001503
Uniprot Accession O43300; LRRT2_HUMAN; A0AVL3; A8K4U9; B7ZLN8; Q7L770;
Genbank Protein ID NP_056379.1;
Genbank Nucleotide ID NM_015564.2;
Protein Name Leucine-rich repeat transmembrane neuronal protein 2
Protein Synonyms/Alias Leucine-rich repeat neuronal 2 protein;
Gene Name LRRTM2
Gene Synonyms/Alias KIAA0416;LRRN2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
18APMLAAIYAMSMVLKcurated23663014
117KLKELILSSNKIFYLcurated24972180
189SLEFLDLSTNRLRSLPhosphoSitePlus22135298
378ATTYRDPTTEYTKRIPhosphoSitePlus22135298
379TTYRDPTTEYTKRISPhosphoSitePlus22135298
381YRDPTTEYTKRISSSPhosphoSitePlus22135298
382RDPTTEYTKRISSSSPhosphoSitePlus22135298
444IIFIVFISRKCCPPTPhosphoSitePlus22135298
511CKCQQLPYKECEV--PhosphoSitePlus22135298
Sequence
(Fasta)		MGLHFKWPLG APMLAAIYAM SMVLKMLPAL GMACPPKCRC EKLLFYCDSQ GFHSVPNATD 60
KGSLGLSLRH NHITELERDQ FASFSQLTWL HLDHNQISTV KEDAFQGLYK LKELILSSNK 120
IFYLPNTTFT QLINLQNLDL SFNQLSSLHP ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC 180
RSLEFLDLST NRLRSLARNG FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK 240
ISNLTCGMEW TWGTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL 300
RSLTTVGLSG NLWECSARIC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI LDAVHGFQLC 360
WNLSTTVTVM ATTYRDPTTE YTKRISSSSY HVGDKEIPTT AGIAVTTEEH FPEPDNAIFT 420
QRVITGTMAL LFSFFFIIFI VFISRKCCPP TLRRIRQCSM VQNHRQLRSQ TRLHMSNMSD 480
QGPYNEYEPT HEGPFIIING YGQCKCQQLP YKECEV 517
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001611--Leu-rich_rpt
IPR003591--Leu-rich_rpt_typical-subtyp
IPR000372--LRRNT
PROSITE

PS51450--LRR
Pfam

PF13855--LRR_8
Gene Ontology

GO:0030054--C:cell junction
GO:0060076--C:excitatory synapse
GO:0016021--C:integral component of membrane
GO:0045211--C:postsynaptic membrane
GO:0060291--P:long-term synaptic potentiation
GO:0002091--P:negative regulation of receptor internalization
GO:0051965--P:positive regulation of synapse assembly
GO:0050808--P:synapse organization