dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0001502 |
| Uniprot Accession | O43299; AP5Z1_HUMAN; Q8N3X2; Q96H80; |
| Genbank Protein ID | NP_055670.1; |
| Genbank Nucleotide ID | NM_014855.2; |
| Protein Name | AP-5 complex subunit zeta-1 |
| Protein Synonyms/Alias | Adaptor-related protein complex 5 zeta subunit;Zeta5; |
| Gene Name | AP5Z1 |
| Gene Synonyms/Alias | KIAA0415;SPG48; |
| Organism | Homo sapiens(Human) |
| NCBI Taxa ID | 9606 |
| Functional Description (View all) |
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MFSAGAESLL HQAREIQDEE LKKFCSRICK LLQAEDLGPD TLDSLQRLFL IISATKYSRR 60 LEKTCVDLLQ ATLGLPACPE QLQVLCAAIL REMSPSDSLS LAWDHTQNSR QLSLVASVLL 120 AQGDRNEEVR AVGQGVLRAL ESRQPEGPSL RHLLPVMAKV VVLSPGTLQE DQATLLSKRL 180 VDWLRYASLQ QGLPHSGGFF STPRARQPGP VTEVDGAVAT DFFTVLSSGH RFTDDQWLNV 240 QAFSMLRAWL LHSGPEGPGT LDTDDRSEQE GSTLSVISAT SSAGRLLPPR ERLREVAFEY 300 CQRLIEQSNR RALRKGDSDL QKACLVEAVL VLDVLCRQDP SFLYRSLSCL KALHGRVRGD 360 PASVRVLLPL AHFFLSHGEA AAVDSEAVYQ HLFTRIPVEQ FHSPMLAFEF IQFCRDNLHL 420 FSGHLSTLRL SFPNLFKFLA WNSPPLTSEF VALLPALVDA GTALEMLHAL LDLPCLTAVL 480 DLQLRSAPAA SERPLWDTSL RAPSCLEAFR DPQFQGLFQY LLRPKASGAT ERLAPLHQLL 540 QPMAGCARVA QCAQAVPTLL QAFFSAVTQV ADGSLINQLA LLLLGRSDSL YPAPGYAAGV 600 HSVLSSQFLA LCTLKPSLVV ELARDLLEFL GSVNGLCSRA SLVTSVVWAI GEYLSVTYDR 660 RCTVEQINKF FEALEALLFE VTQCRPSAAL PRCPPQVVTV LMTTLTKLAS RSQDLIPRAS 720 LLLSKMRTLA HSPATSSTHS EEGAEAIRTR ATELLTLLKM PSVAQFVLTP STEVCSPRYH 780 RDANTALPLA LRTVSRLVER EAGLMPG 808 |
| Keyword | KW-0025--Alternative splicing |
| Interpro | IPR028222--AP5Z1 |
| PROSITE | |
| Pfam | PF14764--SPG48 |
| Gene Ontology | GO:0044599--C:AP-5 adaptor complex |