dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001499
Uniprot Accession O43295; SRGP3_HUMAN; Q8IX13; Q8IZV8;
Genbank Protein ID NP_001028289.1; NP_055665.1;
Genbank Nucleotide ID NM_001033117.2; NM_014850.3;
Protein Name SLIT-ROBO Rho GTPase-activating protein 3
Protein Synonyms/Alias
Gene Name SRGAP3
Gene Synonyms/Alias ARHGAP14;KIAA0411;KIAA1156;MEGAP;SRGAP2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
Phosphorylation Sites
 dbPAF PTMs: 31 (View all)
PositionPeptidesSourceReferences ( PMIDs )
17DKEIIAEYEAQIKEIdbPTM 3.0;PhosphoSitePlus;curated20562096; 16381945; 23193290; 22135298; 22817900
63KAEIELEYSRSLEKLPhosphoSitePlus22135298
80RFSSKIRSSREHQFKPhosphoSitePlus22135298
157HEELLKVTNELYTVMPhosphoSitePlus22135298
161LKVTNELYTVMKTYHPhosphoSitePlus22135298
214DRPQRRSSVKKIEKMPhosphoSitePlus;curated22135298; 23882029
359QTELLMRYHQLQSRLPhosphoSitePlus22135298
392QTLQDMLTVEDFDVSPhosphoSitePlus22135298
399TVEDFDVSDAFQHSRPhosphoSitePlus22135298
405VSDAFQHSRSTESVKcurated23090842
407DAFQHSRSTESVKSAcurated23090842
446YFTKFKEYVNGSNLIPhosphoSitePlus22135298
602ERFQDLISTIKLENPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18088087; 16381945; 23193290; 18988627; 22135298; 19366988;
755EAIAKFDYMGRSPREPhosphoSitePlus22135298
759KFDYMGRSPRELSFKPhosphoSitePlus22135298
764GRSPRELSFKKGASLPhosphoSitePlus22135298
837SSKNDLQSPTEHISDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 18988627; 19060867; 22135298;
839KNDLQSPTEHISDYGcurated23090842
845PTEHISDYGFGGVMGPhosphoSitePlus22135298
858MGRVRLRSDGAAIPRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 20736484; 18988627; 22135298;
Sequence
(Fasta)		MSSQTKFKKD KEIIAEYEAQ IKEIRTQLVE QFKCLEQQSE SRLQLLQDLQ EFFRRKAEIE 60
LEYSRSLEKL AERFSSKIRS SREHQFKKDQ YLLSPVNCWY LVLHQTRRES RDHATLNDIF 120
MNNVIVRLSQ ISEDVIRLFK KSKEIGLQMH EELLKVTNEL YTVMKTYHMY HAESISAESK 180
LKEAEKQEEK QFNKSGDLSM NLLRHEDRPQ RRSSVKKIEK MKEKRQAKYS ENKLKCTKAR 240
NDYLLNLAAT NAAISKYYIH DVSDLIDCCD LGFHASLART FRTYLSAEYN LETSRHEGLD 300
VIENAVDNLD SRSDKHTVMD MCNQVFCPPL KFEFQPHMGD EVCQVSAQQP VQTELLMRYH 360
QLQSRLATLK IENEEVRKTL DATMQTLQDM LTVEDFDVSD AFQHSRSTES VKSAASETYM 420
SKINIAKRRA NQQETEMFYF TKFKEYVNGS NLITKLQAKH DLLKQTLGEG ERAECGTTRP 480
PCLPPKPQKM RRPRPLSVYS HKLFNGSMEA FIKDSGQAIP LVVESCIRYI NLYGLQQQGI 540
FRVPGSQVEV NDIKNSFERG EDPLVDDQNE RDINSVAGVL KLYFRGLENP LFPKERFQDL 600
ISTIKLENPA ERVHQIQQIL VTLPRVVIVV MRYLFAFLNH LSQYSDENMM DPYNLAICFG 660
PTLMHIPDGQ DPVSCQAHIN EVIKTIIIHH EAIFPSPREL EGPVYEKCMA GGEEYCDSPH 720
SEPGAIDEVD HDNGTEPHTS DEEVEQIEAI AKFDYMGRSP RELSFKKGAS LLLYHRASED 780
WWEGRHNGVD GLIPHQYIVV QDMDDAFSDS LSQKADSEAS SGPLLDDKAS SKNDLQSPTE 840
HISDYGFGGV MGRVRLRSDG AAIPRRRSGG DTHSPPRGLG PSIDTPPRAA ACPSSPHKIP 900
LTRGRIESPE KRRMATFGSA GSINYPDKKA LSEGHSMRST CGSTRHSSLG DHKSLEAEAL 960
AEDIEKTMST ALHELRELER QNTVKQAPDV VLDTLEPLKN PPGPVSSEPA SPLHTIVIRD 1020
PDAAMRRSSS SSTEMMTTFK PALSARLAGA QLRPPPMRPV RPVVQHRSSS SSSSGVGSPA 1080
VTPTEKMFPN SSADKSGTM
Keyword

KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0343--GTPase activation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50238--RHOGAP
PS50002--SH3
Pfam

PF00611--FCH
PF00620--RhoGAP
PF00018--SH3_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005096--F:GTPase activator activity
GO:0048365--F:Rac GTPase binding
GO:0030336--P:negative regulation of cell migration
GO:0043547--P:positive regulation of GTPase activity
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007264--P:small GTPase mediated signal transduction