dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001498
Uniprot Accession O43294; TGFI1_HUMAN; B2R8D5; Q9BPW3; Q9Y2V5;
Genbank Protein ID NP_001035919.1; NP_001158191.1; NP_057011.2;
Genbank Nucleotide ID NM_001042454.2; NM_001164719.1; NM_015927.4;
Protein Name Transforming growth factor beta-1-induced transcript 1 protein
Protein Synonyms/Alias Androgen receptor coactivator 55 kDa protein;Androgen receptor-associated protein of 55 kDa;Hydrogen peroxide-inducible clone 5 protein;Hic-5;
Gene Name TGFB1I1
Gene Synonyms/Alias ARA55;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
Phosphorylation Sites
 dbPAF PTMs: 31 (View all)
PositionPeptidesSourceReferences ( PMIDs )
9EDLDALLSDLETTTScurated22199227
33ERPAEPLTPPPSYGHdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 16381945; 23193290; 17081983; 19651622; 18988627;
37EPLTPPPSYGHQPQTPhosphoSitePlus;curated22135298; 24400094; 23403867; 24961811
38PLTPPPSYGHQPQTGPhosphoSitePlus;curated22135298; 23403867; 24961811
44SYGHQPQTGSGESSGdbPTM 3.0;HPRD 9;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 19366988; 23403867;
49PQTGSGESSGASGDKdbPTM 3.0;HPRD 9;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 19366988; 22199227
53SGESSGASGDKDHLYdbPTM 3.0;HPRD 9;SysPTM 2.017081983; 16381945; 23193290; 18988627; 19366988
60SGDKDHLYSTVCKPRdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated10838081; 11856738; 16381945; 23193290; 22135298; 25627689;
61GDKDHLYSTVCKPRSPhosphoSitePlus;curated22135298; 24400094
62DKDHLYSTVCKPRSPPhosphoSitePlus22135298
68STVCKPRSPKPAAPAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 19369195; 16381945; 23193290; 20363803; 19651622;
80APAAPPFSSSSGVLGcurated21857030
82AAPPFSSSSGVLGTGdbPTM 3.0;HPRD 9;curated18691976; 16381945; 23193290; 18988627; 22817900
122FPSSKVASGEQKEDQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated17287340; 16381945; 23193290; 18988627; 22135298; 19366988;
130GEQKEDQSEDKKRPSPhosphoSitePlus22135298
137SEDKKRPSLPSSPSPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated17081983; 16381945; 23193290; 20166139; 20363803; 21406692;
140KKRPSLPSSPSPGLPdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated20166139; 20363803; 16381945; 23193290; 17081983; 19651622;
141KRPSLPSSPSPGLPKdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated20166139; 21406692; 16381945; 23193290; 17081983; 19651622;
143PSLPSSPSPGLPKASdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20166139; 20363803; 19651622;
164ELDRLMASLSDFRVQPhosphoSitePlus;curated22135298; 24400094; 22798277; 24972180
Sequence
(Fasta)		MEDLDALLSD LETTTSHMPR SGAPKERPAE PLTPPPSYGH QPQTGSGESS GASGDKDHLY 60
STVCKPRSPK PAAPAAPPFS SSSGVLGTGL CELDRLLQEL NATQFNITDE IMSQFPSSKV 120
ASGEQKEDQS EDKKRPSLPS SPSPGLPKAS ATSATLELDR LMASLSDFRV QNHLPASGPT 180
QPPVVSSTNE GSPSPPEPTG KGSLDTMLGL LQSDLSRRGV PTQAKGLCGS CNKPIAGQVV 240
TALGRAWHPE HFVCGGCSTA LGGSSFFEKD GAPFCPECYF ERFSPRCGFC NQPIRHKMVT 300
ALGTHWHPEH FCCVSCGEPF GDEGFHEREG RPYCRRDFLQ LFAPRCQGCQ GPILDNYISA 360
LSALWHPDCF VCRECFAPFS GGSFFEHEGR PLCENHFHAR RGSLCATCGL PVTGRCVSAL 420
GRRFHPDHFT CTFCLRPLTK GSFQERAGKP YCQPCFLKLF G 462
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0221--Differentiation
KW-0440--LIM domain
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0879--Wnt signaling pathway
KW-0862--Zinc
Interpro

IPR017305--Tgfb1i1/Leupaxin
IPR001781--Znf_LIM
PROSITE

PS00478--LIM_DOMAIN_1
PS50023--LIM_DOMAIN_2
Pfam

PF00412--LIM
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005925--C:focal adhesion
GO:0005622--C:intracellular
GO:0016363--C:nuclear matrix
GO:0050681--F:androgen receptor binding
GO:0070411--F:I-SMAD binding
GO:0048495--F:Roundabout binding
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0030521--P:androgen receptor signaling pathway
GO:0007155--P:cell adhesion
GO:0045165--P:cell fate commitment
GO:0030855--P:epithelial cell differentiation
GO:0016331--P:morphogenesis of embryonic epithelium
GO:0008285--P:negative regulation of cell proliferation
GO:0045599--P:negative regulation of fat cell differentiation
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0010718--P:positive regulation of epithelial to mesenchymal transition
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0009408--P:response to heat
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
GO:0016055--P:Wnt signaling pathway