dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001496
Uniprot Accession O43292; GPAA1_HUMAN; Q9NSS0; Q9UQ31;
Genbank Protein ID NP_003792.1;
Genbank Nucleotide ID NM_003801.3;
Protein Name Glycosylphosphatidylinositol anchor attachment 1 protein
Protein Synonyms/Alias
Gene Name GPAA1
Gene Synonyms/Alias GAA1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
5---MGLLSDPVRRRAPhosphoSitePlus;curated22135298; 20071362
107GLEVYTQSFSRKLPFdbPTM 3.0;HPRD 917081983; 16381945; 23193290; 18988627
330NSFRQYKYDLVAVGKPhosphoSitePlus22135298
Sequence
(Fasta)
MGLLSDPVRR RALARLVLRL NAPLCVLSYV AGIAWFLALV FPPLTQRTYM SENAMGSTMV 60
EEQFAGGDRA RAFARDFAAH RKKSGALPVA WLERTMRSVG LEVYTQSFSR KLPFPDETHE 120
RYMVSGTNVY GILRAPRAAS TESLVLTVPC GSDSTNSQAV GLLLALAAHF RGQIYWAKDI 180
VFLVTEHDLL GTEAWLEAYH DVNVTGMQSS PLQGRAGAIQ AAVALELSSD VVTSLDVAVE 240
GLNGQLPNLD LLNLFQTFCQ KGGLLCTLQG KLQPEDWTSL DGPLQGLQTL LLMVLRQASG 300
RPHGSHGLFL RYRVEALTLR GINSFRQYKY DLVAVGKALE GMFRKLNHLL ERLHQSFFLY 360
LLPGLSRFVS IGLYMPAVGF LLLVLGLKAL ELWMQLHEAG MGLEEPGGAP GPSVPLPPSQ 420
GVGLASLVAP LLISQAMGLA LYVLPVLGQH VATQHFPVAE AEAVVLTLLA IYAAGLALPH 480
NTHRVVSTQA PDRGWMALKL VALIYLALQL GCIALTNFSL GFLLATTMVP TAALAKPHGP 540
RTLYAALLVL TSPAATLLGS LFLWRELQEA PLSLAEGWQL FLAALAQGVL EHHTYGALLF 600
PLLSLGLYPC WLLFWNVLFW K 622
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0337--GPI-anchor biosynthesis
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007246--Gaa1

PROSITE
Pfam

PF04114--Gaa1

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0042765--C:GPI-anchor transamidase complex
GO:0016020--C:membrane
GO:0015631--F:tubulin binding
GO:0016255--P:attachment of GPI anchor to protein
GO:0006501--P:C-terminal protein lipidation
GO:0044267--P:cellular protein metabolic process
GO:0043687--P:post-translational protein modification
GO:0006461--P:protein complex assembly
GO:0006621--P:protein retention in ER lumen