| Tag |
Content |
| dbPAF ID |
dbPAF-0001495 |
| Uniprot Accession |
O43291; SPIT2_HUMAN; A8K667; B4DLU1; O00271; O14895; Q5TZQ3; Q969E0;
|
| Genbank Protein ID |
NP_001159575.1; NP_066925.1;
|
| Genbank Nucleotide ID |
NM_001166103.1; NM_021102.3;
|
| Protein Name |
Kunitz-type protease inhibitor 2 |
| Protein Synonyms/Alias |
Hepatocyte growth factor activator inhibitor type 2;HAI-2;Placental bikunin; |
| Gene Name |
SPINT2 |
| Gene Synonyms/Alias |
HAI2;KOP; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.Functional Description
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHDFCLV SKVVGRCRAS MPRWWYNVTD 60
GSCQLFVYGG CDGNSNNYLT KEECLKKCAT VTENATGDLA TSRNAADSSV PSAPRRQDSE 120
DHSSDMFNYE EYCTANAVTG PCRASFPRWY FDVERNSCNN FIYGGCRGNK NSYRSEEACM 180
LRCFRQQENP PLPLGSKVVV LAGLFVMVLI LFLGASMVYL IRVARRNQER ALRTVWSSGD 240
DKEQLVKNTY VL
253Fasta Sequence
>O43291|SPINT2|Homo sapiens(Human)
MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-0646--Protease inhibitor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0722--Serine protease inhibitor
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR002223--Kunitz_BPTI
IPR020901--Prtase_inh_Kunz-CS
|
| PROSITE |
PS00280--BPTI_KUNITZ_1
PS50279--BPTI_KUNITZ_2
|
| Pfam |
PF00014--Kunitz_BPTI
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005576--C:extracellular region
GO:0016021--C:integral component of membrane
GO:0004866--F:endopeptidase inhibitor activity
GO:0004867--F:serine-type endopeptidase inhibitor activity
GO:0071711--P:basement membrane organization
GO:0060672--P:epithelial cell morphogenesis involved in placental branching
GO:0007163--P:establishment or maintenance of cell polarity
GO:0006928--P:movement of cell or subcellular component
GO:2000146--P:negative regulation of cell motility
GO:0022408--P:negative regulation of cell-cell adhesion
GO:0010951--P:negative regulation of endopeptidase activity
GO:0001843--P:neural tube closure
|
