dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001494
Uniprot Accession O43290; SNUT1_HUMAN; A6NDN1; Q53GB5;
Genbank Protein ID NP_005137.1;
Genbank Nucleotide ID NM_005146.4;
Protein Name U4/U6.U5 tri-snRNP-associated protein 1
Protein Synonyms/Alias SNU66 homolog;hSnu66;Squamous cell carcinoma antigen recognized by T-cells 1;SART-1;hSART-1;U4/U6.U5 tri-snRNP-associated 110 kDa protein;
Gene Name SART1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.
Phosphorylation Sites
dbPAF PTMs: 58 (View all)
PositionPeptidesSourceReferences ( PMIDs )
17EKEAAGTTAAAGTGGcurated25627689
22GTTAAAGTGGATEQPPhosphoSitePlus;curated22135298; 25627689
42HKKHKHRSGGSGGSGPhosphoSitePlus;curated22135298; 22817900
45HKHRSGGSGGSGGERPhosphoSitePlus22135298
48RSGGSGGSGGERRKRPhosphoSitePlus22135298
84STHGRERSQAEPSERPhosphoSitePlus22135298
102REKRDDGYEAAASSKPhosphoSitePlus22135298
108GYEAAASSKTSSGDAPhosphoSitePlus22135298
110EAAASSKTSSGDASScurated25627689
111AAASSKTSSGDASSLPhosphoSitePlus;curated22135298; 25627689
112AASSKTSSGDASSLSPhosphoSitePlus;curated22135298; 25627689
119SGDASSLSIEETNKLPhosphoSitePlus22135298
123SSLSIEETNKLRAKLdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18491316; 16381945; 23193290; 18988627; 22135298; 22817900
189QKLGKIKTLGEDDPWPhosphoSitePlus;curated22135298; 26074081
200DDPWLDDTAAWIERSPhosphoSitePlus;curated22135298; 26074081
207TAAWIERSRQLQKEKcurated26074081
249GQRRQDLYSARDLQGPhosphoSitePlus22135298
258ARDLQGLTVEHAIDSdbPTM 3.0;PhosphoSitePlus;curated20044836; 16381945; 23193290; 22135298; 22817900
271DSFREGETMILTLKDPhosphoSitePlus22135298
275EGETMILTLKDKGVLdbPTM 3.0;PhosphoSitePlus;curated20044836; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)
MGSSKKHRGE KEAAGTTAAA GTGGATEQPP RHREHKKHKH RSGGSGGSGG ERRKRSRERG 60
GERGSGRRGA EAEARSSTHG RERSQAEPSE RRVKREKRDD GYEAAASSKT SSGDASSLSI 120
EETNKLRAKL GLKPLEVNAI KKEAGTKEEP VTADVINPMA LRQREELREK LAAAKEKRLL 180
NQKLGKIKTL GEDDPWLDDT AAWIERSRQL QKEKDLAEKR AKLLEEMDQE FGVSTLVEEE 240
FGQRRQDLYS ARDLQGLTVE HAIDSFREGE TMILTLKDKG VLQEEEDVLV NVNLVDKERA 300
EKNVELRKKK PDYLPYAEDE SVDDLAQQKP RSILSKYDEE LEGERPHSFR LEQGGTADGL 360
RERELEEIRA KLRLQAQSLS TVGPRLASEY LTPEEMVTFK KTKRRVKKIR KKEKEVVVRA 420
DDLLPLGDQT QDGDFGSRLR GRGRRRVSEV EEEKEPVPQP LPSDDTRVEN MDISDEEEGG 480
APPPGSPQVL EEDEAELELQ KQLEKGRRLR QLQQLQQLRD SGEKVVEIVK KLESRQRGWE 540
EDEDPERKGA IVFNATSEFC RTLGEIPTYG LAGNREEQEE LMDFERDEER SANGGSESDG 600
EENIGWSTVN LDEEKQQQDF SASSTTILDE EPIVNRGLAA ALLLCQNKGL LETTVQKVAR 660
VKAPNKSLPS AVYCIEDKMA IDDKYSRREE YRGFTQDFKE KDGYKPDVKI EYVDETGRKL 720
TPKEAFRQLS HRFHGKGSGK MKTERRMKKL DEEALLKKMS SSDTPLGTVA LLQEKQKAQK 780
TPYIVLSGSG KSMNANTITK 801
Keyword

KW-0002--3D-structure
KW-0020--Allergen
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0747--Spliceosome
KW-0832--Ubl conjugation

Interpro

IPR005011--SNU66/SART1

PROSITE
Pfam

PF03343--SART-1

Gene Ontology

GO:0015030--C:Cajal body
GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0044822--F:poly(A) RNA binding
GO:0007050--P:cell cycle arrest
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0000481--P:maturation of 5S rRNA
GO:0045292--P:mRNA cis splicing, via spliceosome
GO:0000398--P:mRNA splicing, via spliceosome
GO:0045585--P:positive regulation of cytotoxic T cell differentiation
GO:0000387--P:spliceosomal snRNP assembly