dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001491
Uniprot Accession O43281; EFS_HUMAN; B2RAJ7; B4DJ56; E9PGU2; O43282;
Genbank Protein ID NP_001264103.1; NP_005855.1; NP_115835.1;
Genbank Nucleotide ID NM_001277174.1; NM_005864.3; NM_032459.2;
Protein Name Embryonal Fyn-associated substrate
Protein Synonyms/Alias
Gene Name EFS
Gene Synonyms/Alias CASS3;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
123PAGPCPPSPDLIYKIPhosphoSitePlus22135298
128PPSPDLIYKIPRASGPhosphoSitePlus22135298
148PRDALEVYDVPPTALPhosphoSitePlus;curated22135298; 22817900
160TALRVPSSGPYDCPAPhosphoSitePlus22135298
163RVPSSGPYDCPASFSdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 18180459; 16381945; 23193290; 19060867; 22135298;
188PGEDDAPYDVPLTPKPhosphoSitePlus22135298
217REPGPPIYAAPSNLKPhosphoSitePlus22135298
298PHRPRLPSAESLSRRdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19664994; 16381945; 23193290; 18988627; 22135298; 25219547;
319VPEAPSPSPVPSPAPPhosphoSitePlus22135298
323PSPSPVPSPAPGRKGPhosphoSitePlus22135298
372PAGHHNEYEGIPMAEPhosphoSitePlus22135298
381GIPMAEEYDYVHLKGPhosphoSitePlus22135298
383PMAEEYDYVHLKGMDPhosphoSitePlus22135298
Sequence
(Fasta)		MAIATSTQLA RALYDNTAES PQELSFRRGD VLRVLQREGA GGLDGWCLCS LHGQQGIVPA 60
NRVKLLPAGP APKPSLSPAS PAQPGSPYPA PDHSNEDQEV YVVPPPARPC PTSGPPAGPC 120
PPSPDLIYKI PRASGTQLAA PRDALEVYDV PPTALRVPSS GPYDCPASFS HPLTRVAPQP 180
PGEDDAPYDV PLTPKPPAEL EPDLEWEGGR EPGPPIYAAP SNLKRASALL NLYEAPEELL 240
ADGEGGGTDE GIYDVPLLGP EAPPSPEPPG ALASHDQDTL AQLLARSPPP PHRPRLPSAE 300
SLSRRPLPAL PVPEAPSPSP VPSPAPGRKG SIQDRPLPPP PPRLPGYGGP KVEGDPEGRE 360
MEDDPAGHHN EYEGIPMAEE YDYVHLKGMD KAQGSRPPDQ ACTGDPELPE RGMPAPQEAL 420
SPGEPLVVST GDLQLLYFYA GQCQSHYSAL QAAVAALMSS TQANQPPRLF VPHSKRVVVA 480
AHRLVFVGDT LGRLAASAPL RAQVRAAGTA LGQALRATVL AVKGAALGYP SSPAIQEMVQ 540
CVTELAGQAL QFTTLLTSLA P 562
Keyword

KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0729--SH3-binding
Interpro

IPR021901--CAS_DUF3513
IPR001452--SH3_domain
PROSITE

PS50002--SH3
Pfam

PF12026--DUF3513
PF14604--SH3_9
Gene Ontology

GO:0005737--C:cytoplasm
GO:0019904--F:protein domain specific binding
GO:0007155--P:cell adhesion
GO:0035556--P:intracellular signal transduction