| Tag |
Content |
| dbPAF ID |
dbPAF-0001489 |
| Uniprot Accession |
O43278; SPIT1_HUMAN; Q7Z7D2;
|
| Genbank Protein ID |
NP_001027539.1; NP_003701.1; NP_857593.1; XP_006720720.1;
|
| Genbank Nucleotide ID |
NM_001032367.1; NM_003710.3; NM_181642.2; XM_006720657.1;
|
| Protein Name |
Kunitz-type protease inhibitor 1 |
| Protein Synonyms/Alias |
Hepatocyte growth factor activator inhibitor type 1;HAI-1; |
| Gene Name |
SPINT1 |
| Gene Synonyms/Alias |
HAI1;UNQ223/PRO256; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).Functional Description
Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MAPARTMARA RLAPAGIPAV ALWLLCTLGL QGTQAGPPPA PPGLPAGADC LNSFTAGVPG 60
FVLDTNASVS NGATFLESPT VRRGWDCVRA CCTTQNCNLA LVELQPDRGE DAIAACFLIN 120
CLYEQNFVCK FAPREGFINY LTREVYRSYR QLRTQGFGGS GIPKAWAGID LKVQPQEPLV 180
LKDVENTDWR LLRGDTDVRV ERKDPNQVEL WGLKEGTYLF QLTVTSSDHP EDTANVTVTV 240
LSTKQTEDYC LASNKVGRCR GSFPRWYYDP TEQICKSFVY GGCLGNKNNY LREEECILAC 300
RGVQGGPLRG SSGAQATFPQ GPSMERRHPV CSGTCQPTQF RCSNGCCIDS FLECDDTPNC 360
PDASDEAACE KYTSGFDELQ RIHFPSDKGH CVDLPDTGLC KESIPRWYYN PFSEHCARFT 420
YGGCYGNKNN FEEEQQCLES CRGISKKDVF GLRREIPIPS TGSVEMAVAV FLVICIVVVV 480
AILGYCFFKN QRKDFHGHHH HPPPTPASST VSTTEDTEHL VYNHTTRPL
Fasta Sequence
>O43278|SPINT1|Homo sapiens(Human)
MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPGFVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLINCLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLVLKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0621--Polymorphism
KW-0646--Protease inhibitor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0722--Serine protease inhibitor
KW-0732--Signal
|
| Interpro |
IPR002223--Kunitz_BPTI
IPR023415--LDLR_class-A_CS
IPR002172--LDrepeatLR_classA_rpt
IPR013980--MANSC_dom
IPR011106--MANSC_N
IPR020901--Prtase_inh_Kunz-CS
|
| PROSITE |
PS00280--BPTI_KUNITZ_1
PS50279--BPTI_KUNITZ_2
PS01209--LDLRA_1
PS50068--LDLRA_2
PS50986--MANSC
|
| Pfam |
PF00014--Kunitz_BPTI
PF00057--Ldl_recept_a
PF07502--MANEC
|
| Gene Ontology |
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0004867--F:serine-type endopeptidase inhibitor activity
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0010951--P:negative regulation of endopeptidase activity
GO:0001843--P:neural tube closure
GO:0060674--P:placenta blood vessel development
|
