dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001488
Uniprot Accession O43272; PROD_HUMAN; A6NF53; O14680; Q0P507; Q147W8; Q504W1; Q59FI8; Q6NV86; Q9UF13;
Genbank Protein ID NP_001182155.1; NP_057419.4;
Genbank Nucleotide ID NM_001195226.1; NM_016335.4;
Protein Name Proline dehydrogenase 1, mitochondrial
Protein Synonyms/Alias Proline oxidase;Proline oxidase 2;p53-induced gene 6 protein;
Gene Name PRODH
Gene Synonyms/Alias PIG6;POX2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Converts proline to delta-1-pyrroline-5-carboxylate.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
67EAYRSRRTWELARSLcurated26074081
73RTWELARSLLVLRLCcurated26074081
Sequence
(Fasta)		MALRRALPAL RPCIPRFVQL STAPASREQP AAGPAAVPGG GSATAVRPPV PAVDFGNAQE 60
AYRSRRTWEL ARSLLVLRLC AWPALLARHE QLLYVSRKLL GQRLFNKLMK MTFYGHFVAG 120
EDQESIQPLL RHYRAFGVSA ILDYGVEEDL SPEEAEHKEM ESCTSAAERD GSGTNKRDKQ 180
YQAHRAFGDR RNGVISARTY FYANEAKCDS HMETFLRCIE ASGRVSDDGF IAIKLTALGR 240
PQFLLQFSEV LAKWRCFFHQ MAVEQGQAGL AAMDTKLEVA VLQESVAKLG IASRAEIEDW 300
FTAETLGVSG TMDLLDWSSL IDSRTKLSKH LVVPNAQTGQ LEPLLSRFTE EEELQMTRML 360
QRMDVLAKKA TEMGVRLMVD AEQTYFQPAI SRLTLEMQRK FNVEKPLIFN TYQCYLKDAY 420
DNVTLDVELA RREGWCFGAK LVRGAYLAQE RARAAEIGYE DPINPTYEAT NAMYHRCLDY 480
VLEELKHNAK AKVMVASHNE DTVRFALRRM EELGLHPADH QVYFGQLLGM CDQISFPLGQ 540
AGYPVYKYVP YGPVMEVLPY LSRRALENSS LMKGTHRERQ LLWLELLRRL RTGNLFHRPA 600
601
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0274--FAD
KW-0285--Flavoprotein
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-0642--Proline metabolism
KW-1185--Reference proteome
KW-1211--Schizophrenia
KW-0809--Transit peptide
Interpro

IPR029041--FAD-linked_oxidoreductase-like
IPR002872--Proline_DH_dom
IPR015659--Proline_oxidase
PROSITE
Pfam

PF01619--Pro_dh
Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005759--C:mitochondrial matrix
GO:0071949--F:FAD binding
GO:0004657--F:proline dehydrogenase activity
GO:0019470--P:4-hydroxyproline catabolic process
GO:0034641--P:cellular nitrogen compound metabolic process
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0006562--P:proline catabolic process
GO:0010133--P:proline catabolic process to glutamate
GO:0006560--P:proline metabolic process
GO:0044281--P:small molecule metabolic process