| Tag |
Content |
| dbPAF ID |
dbPAF-0001483 |
| Uniprot Accession |
O43251; RFOX2_HUMAN; A4F5G8; A8K5Z5; B0QYY8; B0QYY9; Q0PRL5; Q0VH35; Q5TF71; Q6IC09; Q8TD00; Q8WYB1; Q96DZ6; Q96NL7; Q9UGW4; Q9UH33;
|
| Genbank Protein ID |
NP_001026865.1; NP_001076045.1; NP_001076046.1; NP_001076047.1; NP_001076048.1; NP_055124.1; XP_005261494.1;
|
| Genbank Nucleotide ID |
NM_001031695.2; NM_001082576.1; NM_001082577.1; NM_001082578.1; NM_001082579.1; NM_014309.2; XM_005261437.1;
|
| Protein Name |
RNA binding protein fox-1 homolog 2 |
| Protein Synonyms/Alias |
Fox-1 homolog B;Hexaribonucleotide-binding protein 2;RNA-binding motif protein 9;RNA-binding protein 9;Repressor of tamoxifen transcriptional activity; |
| Gene Name |
RBFOX2 |
| Gene Synonyms/Alias |
FOX2;HRNBP2;RBM9;RTA; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.Functional Description
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MQNEPLTPGY HGFPARDSQG NQEPTTTPDA MVQPFTTIPF PPPPQNGIPT EYGVPHTQDY 60
AGQTGEHNLT LYGSTQAHGE QSSNSPSTQN GSLTTEGGAQ TDGQQSQTQS SENSESKSTP 120
KRLHVSNIPF RFRDPDLRQM FGQFGKILDV EIIFNERGSK GFGFVTFENS ADADRAREKL 180
HGTVVEGRKI EVNNATARVM TNKKMVTPYA NGWKLSPVVG AVYGPELYAA SSFQADVSLG 240
NDAAVPLSGR GGINTYIPLI SLPLVPGFPY PTAATTAAAF RGAHLRGRGR TVYGAVRAVP 300
PTAIPAYPGV VYQDGFYGAD LYGGYAAYRY AQPATATAAT AAAAAAAAYS DGYGRVYTAD 360
PYHALAPAAS YGVGAVASLY RGGYSRFAPY
391Fasta Sequence
>O43251|RBFOX2|Homo sapiens(Human)
MQNEPLTPGYHGFPARDSQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0694--RNA-binding
|
| Interpro |
IPR025670--Fox-1_C_dom
IPR012677--Nucleotide-bd_a/b_plait
IPR017325--RNA-bd_Fox-1
IPR000504--RRM_dom
|
| PROSITE |
PS50102--RRM
|
| Pfam |
PF12414--Fox-1_C
PF00076--RRM_1
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003729--F:mRNA binding
GO:0000166--F:nucleotide binding
GO:0044822--F:poly(A) RNA binding
GO:0003723--F:RNA binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0048813--P:dendrite morphogenesis
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:0006397--P:mRNA processing
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007399--P:nervous system development
GO:0050885--P:neuromuscular process controlling balance
GO:0021942--P:radial glia guided migration of Purkinje cell
GO:0000381--P:regulation of alternative mRNA splicing, via spliceosome
GO:0042127--P:regulation of cell proliferation
GO:0010724--P:regulation of definitive erythrocyte differentiation
GO:0016070--P:RNA metabolic process
GO:0008380--P:RNA splicing
|
