dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001479
Uniprot Accession O43242; PSMD3_HUMAN; B3KMW9; B4DT72; Q96EI2; Q9BQA4;
Genbank Protein ID NP_002800.2;
Genbank Nucleotide ID NM_002809.3;
Protein Name 26S proteasome non-ATPase regulatory subunit 3
Protein Synonyms/Alias 26S proteasome regulatory subunit RPN3;26S proteasome regulatory subunit S3;Proteasome subunit p58;
Gene Name PSMD3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Phosphorylation Sites
dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
6--MKQEGSARRRGADdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22798277; 26074081
43EMKEEAATGGGSTGEPhosphoSitePlus22135298
47EAATGGGSTGEADGKPhosphoSitePlus;curated22135298; 25850435; 25627689; 23917254
48AATGGGSTGEADGKTcurated25627689
105LRMLPSTSRRLNHYVPhosphoSitePlus22135298
264NYLHYSLYDQAEKLVPhosphoSitePlus;curated22135298; 22817900
290NEWARYLYYTGRIKAdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
302IKAIQLEYSEARRTMdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
303KAIQLEYSEARRTMTPhosphoSitePlus;curated22135298; 23186163
392KFQADGTYTLIIRLRPhosphoSitePlus22135298
393FQADGTYTLIIRLRHPhosphoSitePlus22135298
405LRHNVIKTGVRMISLPhosphoSitePlus22135298
413GVRMISLSYSRISLAPhosphoSitePlus22135298
414VRMISLSYSRISLADPhosphoSitePlus22135298
418SLSYSRISLADIAQKdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 23917254;
430AQKLQLDSPEDAEFIPhosphoSitePlus;curated22135298; 25627689; 23917254
450RDGVIEASINHEKGYPhosphoSitePlus22135298
507SYNKDLESAEERRERcurated23186163
532MAEDDDDSFP-----PhosphoSitePlus22135298
Sequence
(Fasta)
MKQEGSARRR GADKAKPPPG GGEQEPPPPP APQDVEMKEE AATGGGSTGE ADGKTAAAAA 60
EHSQRELDTV TLEDIKEHVK QLEKAVSGKE PRFVLRALRM LPSTSRRLNH YVLYKAVQGF 120
FTSNNATRDF LLPFLEEPMD TEADLQFRPR TGKAASTPLL PEVEAYLQLL VVIFMMNSKR 180
YKEAQKISDD LMQKISTQNR RALDLVAAKC YYYHARVYEF LDKLDVVRSF LHARLRTATL 240
RHDADGQATL LNLLLRNYLH YSLYDQAEKL VSKSVFPEQA NNNEWARYLY YTGRIKAIQL 300
EYSEARRTMT NALRKAPQHT AVGFKQTVHK LLIVVELLLG EIPDRLQFRQ PSLKRSLMPY 360
FLLTQAVRTG NLAKFNQVLD QFGEKFQADG TYTLIIRLRH NVIKTGVRMI SLSYSRISLA 420
DIAQKLQLDS PEDAEFIVAK AIRDGVIEAS INHEKGYVQS KEMIDIYSTR EPQLAFHQRI 480
SFCLDIHNMS VKAMRFPPKS YNKDLESAEE RREREQQDLE FAKEMAEDDD DSFP 535
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome

Interpro

IPR013586--26S_Psome_reg_C
IPR013143--PAM
IPR000717--PCI_dom
IPR011990--TPR-like_helical_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE
Pfam

PF01399--PCI
PF08375--Rpn3_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0022624--C:proteasome accessory complex
GO:0000502--C:proteasome complex
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0030234--F:enzyme regulator activity
GO:0000186--P:activation of MAPKK activity
GO:0031145--P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590--P:antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I
GO:0006915--P:apoptotic process
GO:0007411--P:axon guidance
GO:0034641--P:cellular nitrogen compound metabolic process
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0010467--P:gene expression
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0000278--P:mitotic cell cycle
GO:0043066--P:negative regulation of apoptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0038061--P:NIK/NF-kappaB signaling
GO:0006595--P:polyamine metabolic process
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0012501--P:programmed cell death
GO:0000209--P:protein polyubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0042981--P:regulation of apoptotic process
GO:0006521--P:regulation of cellular amino acid metabolic process
GO:0043488--P:regulation of mRNA stability
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0007264--P:small GTPase mediated signal transduction
GO:0044281--P:small molecule metabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016032--P:viral process