Tag |
Content |
dbPAF ID |
dbPAF-0001479 |
Uniprot Accession |
O43242; PSMD3_HUMAN; B3KMW9; B4DT72; Q96EI2; Q9BQA4; |
Genbank Protein ID |
NP_002800.2; |
Genbank Nucleotide ID |
NM_002809.3; |
Protein Name |
26S proteasome non-ATPase regulatory subunit 3 |
Protein Synonyms/Alias |
26S proteasome regulatory subunit RPN3;26S proteasome regulatory subunit S3;Proteasome subunit p58; |
Gene Name |
PSMD3 |
Gene Synonyms/Alias |
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Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.Functional Description
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
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Phosphorylation Sites
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dbPAF PTMs: 19 |
Sequence (Fasta) | MKQEGSARRR GADKAKPPPG GGEQEPPPPP APQDVEMKEE AATGGGSTGE ADGKTAAAAA 60 EHSQRELDTV TLEDIKEHVK QLEKAVSGKE PRFVLRALRM LPSTSRRLNH YVLYKAVQGF 120 FTSNNATRDF LLPFLEEPMD TEADLQFRPR TGKAASTPLL PEVEAYLQLL VVIFMMNSKR 180 YKEAQKISDD LMQKISTQNR RALDLVAAKC YYYHARVYEF LDKLDVVRSF LHARLRTATL 240 RHDADGQATL LNLLLRNYLH YSLYDQAEKL VSKSVFPEQA NNNEWARYLY YTGRIKAIQL 300 EYSEARRTMT NALRKAPQHT AVGFKQTVHK LLIVVELLLG EIPDRLQFRQ PSLKRSLMPY 360 FLLTQAVRTG NLAKFNQVLD QFGEKFQADG TYTLIIRLRH NVIKTGVRMI SLSYSRISLA 420 DIAQKLQLDS PEDAEFIVAK AIRDGVIEAS INHEKGYVQS KEMIDIYSTR EPQLAFHQRI 480 SFCLDIHNMS VKAMRFPPKS YNKDLESAEE RREREQQDLE FAKEMAEDDD DSFP
535Fasta Sequence
>O43242|PSMD3|Homo sapiens(Human) MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP
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Keyword |
KW-0025--Alternative splicing KW-0181--Complete proteome KW-0597--Phosphoprotein KW-0647--Proteasome KW-1185--Reference proteome
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Interpro |
IPR013586--26S_Psome_reg_C IPR013143--PAM IPR000717--PCI_dom IPR011990--TPR-like_helical_dom IPR011991--WHTH_DNA-bd_dom
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PROSITE |
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Pfam |
PF01399--PCI PF08375--Rpn3_C
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0005829--C:cytosol GO:0070062--C:extracellular exosome GO:0016020--C:membrane GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0022624--C:proteasome accessory complex GO:0000502--C:proteasome complex GO:0008541--C:proteasome regulatory particle, lid subcomplex GO:0030234--F:enzyme regulator activity GO:0000186--P:activation of MAPKK activity GO:0031145--P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0042590--P:antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I GO:0006915--P:apoptotic process GO:0007411--P:axon guidance GO:0034641--P:cellular nitrogen compound metabolic process GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007173--P:epidermal growth factor receptor signaling pathway GO:0038095--P:Fc-epsilon receptor signaling pathway GO:0008543--P:fibroblast growth factor receptor signaling pathway GO:0000082--P:G1/S transition of mitotic cell cycle GO:0010467--P:gene expression GO:0045087--P:innate immune response GO:0008286--P:insulin receptor signaling pathway GO:0000165--P:MAPK cascade GO:0000278--P:mitotic cell cycle GO:0043066--P:negative regulation of apoptotic process GO:0090090--P:negative regulation of canonical Wnt signaling pathway GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0048011--P:neurotrophin TRK receptor signaling pathway GO:0038061--P:NIK/NF-kappaB signaling GO:0006595--P:polyamine metabolic process GO:0090263--P:positive regulation of canonical Wnt signaling pathway GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0012501--P:programmed cell death GO:0000209--P:protein polyubiquitination GO:0007265--P:Ras protein signal transduction GO:0042981--P:regulation of apoptotic process GO:0006521--P:regulation of cellular amino acid metabolic process GO:0043488--P:regulation of mRNA stability GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0007264--P:small GTPase mediated signal transduction GO:0044281--P:small molecule metabolic process GO:0002223--P:stimulatory C-type lectin receptor signaling pathway GO:0050852--P:T cell receptor signaling pathway GO:0033209--P:tumor necrosis factor-mediated signaling pathway GO:0006511--P:ubiquitin-dependent protein catabolic process GO:0048010--P:vascular endothelial growth factor receptor signaling pathway GO:0016032--P:viral process
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