dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001478
Uniprot Accession O43237; DC1L2_HUMAN; A8K6V1; B4DZP4; Q8TAT3;
Genbank Protein ID NP_001273086.1; NP_006132.1;
Genbank Nucleotide ID NM_001286157.1; NM_006141.2;
Protein Name Cytoplasmic dynein 1 light intermediate chain 2
Protein Synonyms/Alias Dynein light intermediate chain 2, cytosolic;LIC-2;LIC53/55;
Gene Name DYNC1LI2
Gene Synonyms/Alias DNCLI2;LIC2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
Phosphorylation Sites
 dbPAF PTMs: 36 (View all)
PositionPeptidesSourceReferences ( PMIDs )
26VAAAGDLTSEEEEGQcurated20873877
27AAAGDLTSEEEEGQScurated20873877
34SEEEEGQSLWSSILScurated20873877
184FVKDFQDYMEPEEGCcurated26074081
194PEEGCQGSPQRRGPLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated15302935; 17081983; 18187866; 18669648; 18691976; 19413330;
202PQRRGPLTSGSDEENcurated25627689; 23898821; 20873877; 23836654
203QRRGPLTSGSDEENVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
205RGPLTSGSDEENVALdbPTM 3.0;PhosphoSitePlus;curated19276368; 16381945; 23193290; 22135298; 25627689; 23090842;
220PLGDNVLTHNLGIPVcurated23090842
232IPVLVVCTKCDAVSVcurated23090842; 22199227
284EKNLDLLYKYIVHKTdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
291YKYIVHKTYGFHFTTPhosphoSitePlus;curated22135298; 20071362
292KYIVHKTYGFHFTTPPhosphoSitePlus;curated22135298; 20071362
297KTYGFHFTTPALVVEPhosphoSitePlus;curated22135298; 20071362
336TVKPEDAYEDFIVKPdbPTM 3.0;PhosphoSitePlus21253578; 16381945; 23193290; 22135298
376LLAKQPATPTRASESPhosphoSitePlus;curated22135298; 25627689; 22199227; 23663014
381PATPTRASESPARGPPhosphoSitePlus;curated22135298; 23898821; 23090842
383TPTRASESPARGPSGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 16964243; 20363803; 22115753;
389ESPARGPSGSPRTQGdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18691976; 16381945; 23193290; 18988627; 22135298; 25627689;
391PARGPSGSPRTQGRGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 16964243; 20068231; 20363803;
Sequence
(Fasta)		MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK LPSGKNILVF 60
GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD HTRCNVWILD GDLYHKGLLK 120
FAVSAESLPE TLVIFVADMS RPWTVMESLQ KWASVLREHI DKMKIPPEKM RELERKFVKD 180
FQDYMEPEEG CQGSPQRRGP LTSGSDEENV ALPLGDNVLT HNLGIPVLVV CTKCDAVSVL 240
EKEHDYRDEH LDFIQSHLRR FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTTPA 300
LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH DKELAAEDEQ 360
VFLMKQQSLL AKQPATPTRA SESPARGPSG SPRTQGRGGP ASVPSSSPGT SVKKPDPNIK 420
NNAASEGVLA SFFNSLLSKK TGSPGSPGAG GVQSTAKKSG QKTVLSNVQE ELDRMTRKPD 480
SMVTNSSTEN EA 493
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0243--Dynein
KW-0493--Microtubule
KW-0505--Motor protein
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR008467--Dynein1_light_intermed_chain
IPR022780--Dynein_light_int_chain
IPR027417--P-loop_NTPase
PROSITE
Pfam

PF05783--DLIC
Gene Ontology

GO:0005813--C:centrosome
GO:0005868--C:cytoplasmic dynein complex
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0005524--F:ATP binding
GO:0003777--F:microtubule motor activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0051642--P:centrosome localization
GO:0000226--P:microtubule cytoskeleton organization
GO:0007018--P:microtubule-based movement
GO:0006810--P:transport