| Tag |
Content |
| dbPAF ID |
dbPAF-0001477 |
| Uniprot Accession |
O43236; SEPT4_HUMAN; B2RD42; B3KSX9; B4DXC6; B4DXV5; Q6IAP3; Q9H315; Q9UM58;
|
| Genbank Protein ID |
NP_001185642.1; NP_001243711.1; NP_001243751.1; NP_004565.1; NP_536340.1; NP_536341.1; XP_006722017.1; XP_006722018.1; XP_011523213.1; XP_011523214.1;
|
| Genbank Nucleotide ID |
NM_001198713.1; NM_001256782.1; NM_001256822.1; NM_004574.4; NM_080415.3; NM_080416.3; XM_006721954.1; XM_006721955.1; XM_011524911.1; XM_011524912.1;
|
| Protein Name |
Septin-4 |
| Protein Synonyms/Alias |
Apoptosis-related protein in the TGF-beta signaling pathway;ARTS;Bradeion beta;Brain protein H5;CE5B3 beta;Cell division control-related protein 2;hCDCREL-2;Cerebral protein 7;Peanut-like protein 2; |
| Gene Name |
SEPT4 |
| Gene Synonyms/Alias |
ARTS;PNUTL2;SEP4;hucep-7; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.Functional Description
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MDRSLGWQGN SVPEDRTEAG IKRFLEDTTD DGELSKFVKD FSGNASCHPP EAKTWASRPQ 60
VPEPRPQAPD LYDDDLEFRP PSRPQSSDNQ QYFCAPAPLS PSARPRSPWG KLDPYDSSED 120
DKEYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL VNSLFLTDLY RDRKLLGAEE 180
RIMQTVEITK HAVDIEEKGV RLRLTIVDTP GFGDAVNNTE CWKPVAEYID QQFEQYFRDE 240
SGLNRKNIQD NRVHCCLYFI SPFGHGLRPL DVEFMKALHQ RVNIVPILAK ADTLTPPEVD 300
HKKRKIREEI EHFGIKIYQF PDCDSDEDED FKLQDQALKE SIPFAVIGSN TVVEARGRRV 360
RGRLYPWGIV EVENPGHCDF VKLRTMLVRT HMQDLKDVTR ETHYENYRAQ CIQSMTRLVV 420
KERNRNKLTR ESGTDFPIPA VPPGTDPETE KLIREKDEEL RRMQEMLHKI QKQMKENY
479Fasta Sequence
>O43236|SEPT4|Homo sapiens(Human)
MDRSLGWQGNSVPEDRTEAGIKRFLEDTTDDGELSKFVKDFSGNASCHPPEAKTWASRPQVPEPRPQAPDLYDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY
|
| Keyword |
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0342--GTP-binding
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
|
| Interpro |
IPR030379--G_SEPTIN_dom
IPR027417--P-loop_NTPase
IPR016491--Septin
IPR030643--Septin4
|
| PROSITE |
PS51719--G_SEPTIN
|
| Pfam |
PF00735--Septin
|
| Gene Ontology |
GO:0005856--C:cytoskeleton
GO:0005739--C:mitochondrion
GO:0043209--C:myelin sheath
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0097227--C:sperm annulus
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0005198--F:structural molecule activity
GO:0006915--P:apoptotic process
GO:0007420--P:brain development
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0043065--P:positive regulation of apoptotic process
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0031398--P:positive regulation of protein ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0048240--P:sperm capacitation
GO:0030382--P:sperm mitochondrion organization
|
