dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001476
Uniprot Accession O43196; MSH5_HUMAN; B0V033; B0V034; O60586; Q5BLU9; Q5SSR1; Q8IW44; Q9BQC7;
Genbank Protein ID NP_002432.1; NP_079535.4; NP_751897.1; NP_751898.1;
Genbank Nucleotide ID NM_002441.4; NM_025259.5; NM_172165.3; NM_172166.3;
Protein Name MutS protein homolog 5
Protein Synonyms/Alias
Gene Name MSH5
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity).
Phosphorylation Sites
dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
235SVLQIFKSESHPSVYPhosphoSitePlus22135298
237LQIFKSESHPSVYKVPhosphoSitePlus22135298
240FKSESHPSVYKVASGPhosphoSitePlus22135298
242SESHPSVYKVASGLKPhosphoSitePlus22135298
537DVLLALASAARDYGYPhosphoSitePlus22135298
549YGYSRPRYSPQVLGVPhosphoSitePlus22135298
742GNDLVFFYQVCEGVAPhosphoSitePlus22135298
Sequence
(Fasta)
MASLGANPRR TPQGPRPGAA SSGFPSPAPV PGPREAEEEE VEEEEELAEI HLCVLWNSGY 60
LGIAYYDTSD STIHFMPDAP DHESLKLLQR VLDEINPQSV VTSAKQDENM TRFLGKLASQ 120
EHREPKRPEI IFLPSVDFGL EISKQRLLSG NYSFIPDAMT ATEKILFLSS IIPFDCLLTV 180
RALGGLLKFL GRRRIGVELE DYNVSVPILG FKKFMLTHLV NIDQDTYSVL QIFKSESHPS 240
VYKVASGLKE GLSLFGILNR CHCKWGEKLL RLWFTRPTHD LGELSSRLDV IQFFLLPQNL 300
DMAQMLHRLL GHIKNVPLIL KRMKLSHTKV SDWQVLYKTV YSALGLRDAC RSLPQSIQLF 360
RDIAQEFSDD LHHIASLIGK VVDFEGSLAE NRFTVLPNID PEIDEKKRRL MGLPSFLTEV 420
ARKELENLDS RIPSCSVIYI PLIGFLLSIP RLPSMVEASD FEINGLDFMF LSEEKLHYRS 480
ARTKELDALL GDLHCEIRDQ ETLLMYQLQC QVLARAAVLT RVLDLASRLD VLLALASAAR 540
DYGYSRPRYS PQVLGVRIQN GRHPLMELCA RTFVPNSTEC GGDKGRVKVI TGPNSSGKSI 600
YLKQVGLITF MALVGSFVPA EEAEIGAVDA IFTRIHSCES ISLGLSTFMI DLNQVAKAVN 660
NATAQSLVLI DEFGKGTNTV DGLALLAAVL RHWLARGPTC PHIFVATNFL SLVQLQLLPQ 720
GPLVQYLTME TCEDGNDLVF FYQVCEGVAK ASHASHTAAQ AGLPDKLVAR GKEVSDLIRS 780
GKPIKPVKDL LKKNQMENCQ TLVDKFMKLD LEDPNLDLNV FMSQEVLPAA TSIL 835
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0469--Meiosis
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR011184--DNA_mismatch_repair_MutS
IPR000432--DNA_mismatch_repair_MutS_C
IPR007861--DNA_mismatch_repair_MutS_clamp
IPR007696--DNA_mismatch_repair_MutS_core
IPR027417--P-loop_NTPase

PROSITE

PS00486--DNA_MISMATCH_REPAIR_2

Pfam

PF05192--MutS_III
PF05190--MutS_IV
PF00488--MutS_V

Gene Ontology

GO:0000228--C:nuclear chromosome
GO:0000795--C:synaptonemal complex
GO:0005524--F:ATP binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0030983--F:mismatched DNA binding
GO:0051026--P:chiasma assembly
GO:0045143--P:homologous chromosome segregation
GO:0006298--P:mismatch repair
GO:0007131--P:reciprocal meiotic recombination