dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001475
Uniprot Accession O43194; GPR39_HUMAN; B2RC12; B6V9G4; Q08AS2; Q53R01;
Genbank Protein ID NP_001499.1;
Genbank Nucleotide ID NM_001508.2;
Protein Name G-protein coupled receptor 39
Protein Synonyms/Alias
Gene Name GPR39
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
51GLLGNSATIRVTQVLPhosphoSitePlus22135298
256LMKSQKGSLAGGTRPcurated24961811
281SRTARRQTIIFLRLIPhosphoSitePlus22135298
396QRPLLFASRRQSSARPhosphoSitePlus;curated22135298; 23898821; 24961811
423EAEPQSKSQSLSLEScurated23090842
425EPQSKSQSLSLESLEcurated23090842
427QSKSQSLSLESLEPNcurated23898821; 25849741
430SQSLSLESLEPNSGAPhosphoSitePlus;curated22135298; 23898821; 25849741
Sequence
(Fasta)		MASPSLPGSD CSQIIDHSHV PEFEVATWIK ITLILVYLII FVMGLLGNSA TIRVTQVLQK 60
KGYLQKEVTD HMVSLACSDI LVFLIGMPME FYSIIWNPLT TSSYTLSCKL HTFLFEACSY 120
ATLLHVLTLS FERYIAICHP FRYKAVSGPC QVKLLIGFVW VTSALVALPL LFAMGTEYPL 180
VNVPSHRGLT CNRSSTRHHE QPETSNMSIC TNLSSRWTVF QSSIFGAFVV YLVVLLSVAF 240
MCWNMMQVLM KSQKGSLAGG TRPPQLRKSE SEESRTARRQ TIIFLRLIVV TLAVCWMPNQ 300
IRRIMAAAKP KHDWTRSYFR AYMILLPFSE TFFYLSSVIN PLLYTVSSQQ FRRVFVQVLC 360
CRLSLQHANH EKRLRVHAHS TTDSARFVQR PLLFASRRQS SARRTEKIFL STFQSEAEPQ 420
SKSQSLSLES LEPNSGAKPA NSAAENGFQE HEV 454
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
Interpro

IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
PROSITE

PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2
Pfam

PF00001--7tm_1
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0004930--F:G-protein coupled receptor activity
GO:0046872--F:metal ion binding
GO:0008343--P:adult feeding behavior
GO:0071294--P:cellular response to zinc ion
GO:0042632--P:cholesterol homeostasis
GO:0002024--P:diet induced thermogenesis
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0035483--P:gastric emptying
GO:0042593--P:glucose homeostasis
GO:0060455--P:negative regulation of gastric acid secretion
GO:0035774--P:positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:0019216--P:regulation of lipid metabolic process
GO:0042391--P:regulation of membrane potential