dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001472
Uniprot Accession O43187; IRAK2_HUMAN; B4DQZ6; Q08AG6; Q5K546;
Genbank Protein ID NP_001561.3;
Genbank Nucleotide ID NM_001570.3;
Protein Name Interleukin-1 receptor-associated kinase-like 2
Protein Synonyms/Alias
Gene Name IRAK2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
4----MACYIYQLPSWPhosphoSitePlus22135298
6--MACYIYQLPSWVLPhosphoSitePlus22135298
143ATFPGPGSSPARAHQcurated25627689; 23403867
144TFPGPGSSPARAHQPPhosphoSitePlus;curated22135298; 25627689; 23917254; 24961811
430YLKDLLLSDIPSSTAPhosphoSitePlus22135298
434LLLSDIPSSTASLCSPhosphoSitePlus22135298
438DIPSSTASLCSRKTGPhosphoSitePlus22135298
Sequence
(Fasta)		MACYIYQLPS WVLDDLCRNM DALSEWDWME FASYVITDLT QLRKIKSMER VQGVSITREL 60
LWWWGMRQAT VQQLVDLLCR LELYRAAQII LNWKPAPEIR CPIPAFPDSV KPEKPLAASV 120
RKAEDEQEEG QPVRMATFPG PGSSPARAHQ PAFLQPPEED APHSLRSDLP TSSDSKDFST 180
SIPKQEKLLS LAGDSLFWSE ADVVQATDDF NQNRKISQGT FADVYRGHRH GKPFVFKKLR 240
ETACSSPGSI ERFFQAELQI CLRCCHPNVL PVLGFCAARQ FHSFIYPYMA NGSLQDRLQG 300
QGGSDPLPWP QRVSICSGLL CAVEYLHGLE IIHSNVKSSN VLLDQNLTPK LAHPMAHLCP 360
VNKRSKYTMM KTHLLRTSAA YLPEDFIRVG QLTKRVDIFS CGIVLAEVLT GIPAMDNNRS 420
PVYLKDLLLS DIPSSTASLC SRKTGVENVM AKEICQKYLE KGAGRLPEDC AEALATAACL 480
CLRRRNTSLQ EVCGSVAAVE ERLRGRETLL PWSGLSEGTG SSSNTPEETD DVDNSSLDAS 540
SSMSVAPWAG AATPLLPTEN GEGRLRVIVG READSSSEAC VGLEPPQDVT ETSWQIEINE 600
AKRKLMENIL LYKEEKVDSI ELFGP 626
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR011029--DEATH-like_dom
IPR000488--Death_domain
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
PROSITE

PS50011--PROTEIN_KINASE_DOM
Pfam

PF00531--Death
PF00069--Pkinase
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0000187--P:activation of MAPK activity
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0007254--P:JNK cascade
GO:0031663--P:lipopolysaccharide-mediated signaling pathway
GO:0002755--P:MyD88-dependent toll-like receptor signaling pathway
GO:0002756--P:MyD88-independent toll-like receptor signaling pathway
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0035872--P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006468--P:protein phosphorylation
GO:0001959--P:regulation of cytokine-mediated signaling pathway
GO:0070555--P:response to interleukin-1
GO:0051403--P:stress-activated MAPK cascade
GO:0034166--P:toll-like receptor 10 signaling pathway
GO:0034134--P:toll-like receptor 2 signaling pathway
GO:0034138--P:toll-like receptor 3 signaling pathway
GO:0034142--P:toll-like receptor 4 signaling pathway
GO:0034146--P:toll-like receptor 5 signaling pathway
GO:0034162--P:toll-like receptor 9 signaling pathway
GO:0002224--P:toll-like receptor signaling pathway
GO:0038123--P:toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124--P:toll-like receptor TLR6:TLR2 signaling pathway
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway