| Tag |
Content |
| dbPAF ID |
dbPAF-0001471 |
| Uniprot Accession |
O43186; CRX_HUMAN; Q0QD45;
|
| Genbank Protein ID |
NP_000545.1;
|
| Genbank Nucleotide ID |
NM_000554.4;
|
| Protein Name |
Cone-rod homeobox protein |
| Protein Synonyms/Alias |
|
| Gene Name |
CRX |
| Gene Synonyms/Alias |
CORD2; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.Functional Description
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MMAYMNPGPH YSVNALALSG PSVDLMHQAV PYPSAPRKQR RERTTFTRSQ LEELEALFAK 60
TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ QKQQQQPPGG QAKARPAKRK 120
AGTSPRPSTD VCPDPLGISD SYSPPLPGPS GSPTTAVATV SIWSPASESP LPEAQRAGLV 180
ASGPSLTSAP YAMTYAPASA FCSSPSAYGS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP 240
SVGPSLAQSP TSLSGQSYGA YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL
300
Fasta Sequence
>O43186|CRX|Homo sapiens(Human)
MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGPSVGPSLAQSPTSLSGQSYGAYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL
|
| Keyword |
KW-0010--Activator
KW-0181--Complete proteome
KW-0182--Cone-rod dystrophy
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0901--Leber congenital amaurosis
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0682--Retinitis pigmentosa
KW-0716--Sensory transduction
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0844--Vision
|
| Interpro |
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR009057--Homeodomain-like
IPR013851--Otx_TF_C
|
| PROSITE |
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
|
| Pfam |
PF00046--Homeobox
PF03529--TF_Otx
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0043522--F:leucine zipper domain binding
GO:0035257--F:nuclear hormone receptor binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0007623--P:circadian rhythm
GO:0009887--P:organ morphogenesis
GO:0046534--P:positive regulation of photoreceptor cell differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0050896--P:response to stimulus
GO:0060041--P:retina development in camera-type eye
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0007601--P:visual perception
|
