| Tag |
Content |
| dbPAF ID |
dbPAF-0001470 |
| Uniprot Accession |
O43184; ADA12_HUMAN; O60470; Q5JRP0; Q5JRP1; Q6P9E3; Q6UWB0;
|
| Genbank Protein ID |
NP_001275903.1; NP_001275904.1; NP_003465.3; NP_067673.2;
|
| Genbank Nucleotide ID |
NM_001288974.1; NM_001288975.1; NM_003474.5; NM_021641.4;
|
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 12 |
| Protein Synonyms/Alias |
|
| Gene Name |
ADAM12 |
| Gene Synonyms/Alias |
MLTN;UNQ346/PRO545; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).Functional Description
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG DLWIPVKSFD 60
SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL QDGTDVSLAR NYTVILGHCY 120
YHGHVRGYSD SAVSLSTCSG LRGLIVFENE SYVLEPMKSA TNRYKLFPAK KLKSVRGSCG 180
SHHNTPNLAA KNVFPPPSQT WARRHKRETL KATKYVELVI VADNREFQRQ GKDLEKVKQR 240
LIEIANHVDK FYRPLNIRIV LVGVEVWNDM DKCSVSQDPF TSLHEFLDWR KMKLLPRKSH 300
DNAQLVSGVY FQGTTIGMAP IMSMCTADQS GGIVMDHSDN PLGAAVTLAH ELGHNFGMNH 360
DTLDRGCSCQ MAVEKGGCIM NASTGYPFPM VFSSCSRKDL ETSLEKGMGV CLFNLPEVRE 420
SFGGQKCGNR FVEEGEECDC GEPEECMNRC CNATTCTLKP DAVCAHGLCC EDCQLKPAGT 480
ACRDSSNSCD LPEFCTGASP HCPANVYLHD GHSCQDVDGY CYNGICQTHE QQCVTLWGPG 540
AKPAPGICFE RVNSAGDPYG NCGKVSKSSF AKCEMRDAKC GKIQCQGGAS RPVIGTNAVS 600
IETNIPLQQG GRILCRGTHV YLGDDMPDPG LVLAGTKCAD GKICLNRQCQ NISVFGVHEC 660
AMQCHGRGVC NNRKNCHCEA HWAPPFCDKF GFGGSTDSGP IRQADNQGLT IGILVTILCL 720
LAAGFVVYLK RKTLIRLLFT NKKTTIEKLR CVRPSRPPRG FQPCQAHLGH LGKGLMRKPP 780
DSYPPKDNPR RLLQCQNVDI SRPLNGLNVP QPQSTQRVLP PLHRAPRAPS VPARPLPAKP 840
ALRQAQGTCK PNPPQKPLPA DPLARTTRLT HALARTPGQW ETGLRLAPLR PAPQYPHQVP 900
RSTHTAYIK
Fasta Sequence
>O43184|ADAM12|Homo sapiens(Human)
MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTAYIK
|
| Keyword |
KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0964--Secreted
KW-0729--SH3-binding
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0865--Zymogen
|
| Interpro |
IPR006586--ADAM_Cys-rich
IPR018358--Disintegrin_CS
IPR001762--Disintegrin_dom
IPR000742--EGF-like_dom
IPR024079--MetalloPept_cat_dom
IPR001590--Peptidase_M12B
IPR002870--Peptidase_M12B_N
|
| PROSITE |
PS50215--ADAM_MEPRO
PS00427--DISINTEGRIN_1
PS50214--DISINTEGRIN_2
PS50026--EGF_3
PS00142--ZINC_PROTEASE
|
| Pfam |
PF08516--ADAM_CR
PF00200--Disintegrin
PF01562--Pep_M12B_propep
PF01421--Reprolysin
|
| Gene Ontology |
GO:0005576--C:extracellular region
GO:0016021--C:integral component of membrane
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004222--F:metalloendopeptidase activity
GO:0008237--F:metallopeptidase activity
GO:0017124--F:SH3 domain binding
GO:0008270--F:zinc ion binding
GO:0007155--P:cell adhesion
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007520--P:myoblast fusion
|
