dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001469
Uniprot Accession O43182; RHG06_HUMAN; B2RWQ0; O43437; Q9P1B3; Q9UK81; Q9UK82;
Genbank Protein ID NP_001274171.1; NP_006116.2; NP_038267.1; NP_038286.2;
Genbank Nucleotide ID NM_001287242.1; NM_006125.2; NM_013423.2; NM_013427.2;
Protein Name Rho GTPase-activating protein 6
Protein Synonyms/Alias Rho-type GTPase-activating protein 6;Rho-type GTPase-activating protein RhoGAPX-1;
Gene Name ARHGAP6
Gene Synonyms/Alias RHOGAP6;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.
Phosphorylation Sites
 dbPAF PTMs: 39 (View all)
PositionPeptidesSourceReferences ( PMIDs )
69AGRLYSPSLPAESLGPhosphoSitePlus22135298
74SPSLPAESLGPRLASPhosphoSitePlus22135298
141SMAWDLPSVLAGPASPhosphoSitePlus22135298
213GRSVRLRSVPIQSLSdbPTM 3.018785766; 16381945; 23193290
264SLRKKLDSLGKEKNKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18088087; 16381945; 23193290; 18988627; 22135298; 19366988;
328KRQNKELSSSNSSLScurated23186163; 25262027
329RQNKELSSSNSSLSScurated25262027
332KELSSSNSSLSSTSEcurated25262027
335SSSNSSLSSTSETPNcurated25262027
336SSNSSLSSTSETPNEcurated25262027
337SNSSLSSTSETPNEScurated23186163
338NSSLSSTSETPNESTcurated23186163
349NESTSPNTPEPAPRAPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 22199227
363ARRRGAMSVDSITDLPhosphoSitePlus;curated22135298; 23917254; 23186163; 25262027
366RGAMSVDSITDLDDNPhosphoSitePlus;curated22135298; 23917254; 25262027
407KLSLNPIYRQVPRLVPhosphoSitePlus;curated22135298; 22817900
551VTGNKMTSLNLATIFdbPTM 3.018088087; 16381945; 23193290
569LLHKQKSSDKEFSVQdbPTM 3.018077418; 20058876; 16381945; 23193290
574KSSDKEFSVQSSARAdbPTM 3.018088087; 16381945; 23193290
633YLLRRKASQSSSPDMPhosphoSitePlus;curated22135298; 23917254
Sequence
(Fasta)		MSAQSLLHSV FSCSSPASSS AASAKGFSKR KLRQTRSLDP ALIGGCGSDE AGAEGSARGA 60
TAGRLYSPSL PAESLGPRLA SSSRGPPPRA TRLPPPGPLC SSFSTPSTPQ EKSPSGSFHF 120
DYEVPLGRGG LKKSMAWDLP SVLAGPASSR SASSILCSSG GGPNGIFASP RRWLQQRKFQ 180
SPPDSRGHPY VVWKSEGDFT WNSMSGRSVR LRSVPIQSLS ELERARLQEV AFYQLQQDCD 240
LSCQITIPKD GQKRKKSLRK KLDSLGKEKN KDKEFIPQAF GMPLSQVIAN DRAYKLKQDL 300
QRDEQKDASD FVASLLPFGN KRQNKELSSS NSSLSSTSET PNESTSPNTP EPAPRARRRG 360
AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK LSLNPIYRQV PRLVDSCCQH 420
LEKHGLQTVG IFRVGSSKKR VRQLREEFDR GIDVSLEEEH SVHDVAALLK EFLRDMPDPL 480
LTRELYTAFI NTLLLEPEEQ LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNISKD 540
GQEVTGNKMT SLNLATIFGP NLLHKQKSSD KEFSVQSSAR AEESTAIIAV VQKMIENYEA 600
LFMVPPDLQN EVLISLLETD PDVVDYLLRR KASQSSSPDM LQSEVSFSVG GRHSSTDSNK 660
ASSGDISPYD NNSPVLSERS LLAMQEDAAP GGSEKLYRVP GQFMLVGHLS SSKSRESSPG 720
PRLGKDLSEE PFDIWGTWHS TLKSGSKDPG MTGSSGDIFE SSSLRAGPCS LSQGNLSPNW 780
PRWQGSPAEL DSDTQGARRT QAAAPATEGR AHPAVSRACS TPHVQVAGKA ERPTARSEQY 840
LTLSGAHDLS ESELDVAGLQ SRATPQCQRP HGSGRDDKRP PPPYPGPGKP AAAAAWIQGP 900
PEGVETPTDQ GGQAAEREQQ VTQKKLSSAN SLPAGEQDSP RLGDAGWLDW QRERWQIWEL 960
LSTDNPDALP ETLV 975
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0343--GTPase activation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0729--SH3-binding
Interpro

IPR008936--Rho_GTPase_activation_prot
IPR030772--RhoGAP6
IPR000198--RhoGAP_dom
PROSITE

PS50238--RHOGAP
Pfam

PF00620--RhoGAP
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005884--C:actin filament
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005096--F:GTPase activator activity
GO:0016004--F:phospholipase activator activity
GO:0043274--F:phospholipase binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0030041--P:actin filament polymerization
GO:0007202--P:activation of phospholipase C activity
GO:0048041--P:focal adhesion assembly
GO:0051895--P:negative regulation of focal adhesion assembly
GO:0051497--P:negative regulation of stress fiber assembly
GO:0010518--P:positive regulation of phospholipase activity
GO:0009967--P:positive regulation of signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007266--P:Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction