dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001468
Uniprot Accession O43181; NDUS4_HUMAN; Q9BS69;
Genbank Protein ID NP_002486.1;
Genbank Nucleotide ID NM_002495.2;
Protein Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Protein Synonyms/Alias Complex I-18 kDa;CI-18 kDa;Complex I-AQDQ;CI-AQDQ;NADH-ubiquinone oxidoreductase 18 kDa subunit;
Gene Name NDUFS4
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
32LSVSRVPTRSLRTSTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated16094384; 16381945; 23193290; 18988627; 22135298; 22817900
34VSRVPTRSLRTSTWRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated16094384; 16381945; 23193290; 18988627; 22135298; 22817900
157RKVPKPKSKSYGANFdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
165KSYGANFSWNKRTRVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
173WNKRTRVSTK-----dbPTM 3.0;PhosphoSitePlus18291624; 20433953; 16381945; 23193290; 22135298
Sequence
(Fasta)		MAAVSMSVVL RQTLWRRRAV AVAALSVSRV PTRSLRTSTW RLAQDQTQDT QLITVDEKLD 60
ITTLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME FDTRERWENP LMGWASTADP 120
LSNMVLTFST KEDAVSFAEK NGWSYDIEER KVPKPKSKSY GANFSWNKRT RVSTK 176
Keyword

KW-0181--Complete proteome
KW-0249--Electron transport
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0679--Respiratory chain
KW-0809--Transit peptide
KW-0813--Transport
Interpro

IPR006885--NADH_UbQ_FeS_4_mit
PROSITE
Pfam

PF04800--ETC_C1_NDUFA4
Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005747--C:mitochondrial respiratory chain complex I
GO:0005739--C:mitochondrion
GO:0008137--F:NADH dehydrogenase (ubiquinone) activity
GO:0007420--P:brain development
GO:0019933--P:cAMP-mediated signaling
GO:0044237--P:cellular metabolic process
GO:0045333--P:cellular respiration
GO:0006120--P:mitochondrial electron transport, NADH to ubiquinone
GO:0032981--P:mitochondrial respiratory chain complex I assembly
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0072593--P:reactive oxygen species metabolic process
GO:0001932--P:regulation of protein phosphorylation
GO:0022904--P:respiratory electron transport chain
GO:0051591--P:response to cAMP
GO:0044281--P:small molecule metabolic process