dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0001466 |
| Uniprot Accession | O43174; CP26A_HUMAN; B3KNI4; Q5VXH9; Q5VXI0; |
| Genbank Protein ID | NP_000774.2; NP_476498.1; |
| Genbank Nucleotide ID | NM_000783.3; NM_057157.2; |
| Protein Name | Cytochrome P450 26A1 |
| Protein Synonyms/Alias | Cytochrome P450 retinoic acid-inactivating 1;Cytochrome P450RAI;hP450RAI;Retinoic acid 4-hydroxylase;Retinoic acid-metabolizing cytochrome; |
| Gene Name | CYP26A1 |
| Gene Synonyms/Alias | CYP26;P450RAI1; |
| Organism | Homo sapiens(Human) |
| NCBI Taxa ID | 9606 |
| Functional Description (View all) |
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MGLPALLASA LCTFVLPLLL FLAAIKLWDL YCVSGRDRSC ALPLPPGTMG FPFFGETLQM 60 VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL 120 GSGCLSNLHD SSHKQRKKVI MRAFSREALE CYVPVITEEV GSSLEQWLSC GERGLLVYPE 180 VKRLMFRIAM RILLGCEPQL AGDGDSEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGMKAR 240 NLIHARIEQN IRAKICGLRA SEAGQGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG 300 GHETTASAAT SLITYLGLYP HVLQKVREEL KSKGLLCKSN QDNKLDMEIL EQLKYIGCVI 360 KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVAEIFTN KEEFNPDRFM 420 LPHPEDASRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RHCDWQLLNG PPTMKTSPTV 480 YPVDNLPARF THFHGEI 498 |
| Keyword | KW-0025--Alternative splicing |
| Interpro | IPR001128--Cyt_P450 |
| PROSITE | PS00086--CYTOCHROME_P450 |
| Pfam | PF00067--p450 |
| Gene Ontology | GO:0005789--C:endoplasmic reticulum membrane |