dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001465
Uniprot Accession O43173; SIA8C_HUMAN; A8K0F2; Q6B085; Q9NS41;
Genbank Protein ID NP_056963.2;
Genbank Nucleotide ID NM_015879.2;
Protein Name Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
Protein Synonyms/Alias Alpha-2,8-sialyltransferase 8C;Alpha-2,8-sialyltransferase III;ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3;Sialyltransferase 8C;SIAT8-C;Sialyltransferase St8Sia III;ST8SiaIII;
Gene Name ST8SIA3
Gene Synonyms/Alias SIAT8C;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
41KKENIFTTPKYASPGPhosphoSitePlus22135298
46FTTPKYASPGAPRMYPhosphoSitePlus22135298
213NLTTFNPSILEKYYNPhosphoSitePlus22135298
295YWKNKHLSPKRLSTGPhosphoSitePlus22135298
Sequence
(Fasta)		MRNCKMARVA SVLGLVMLSV ALLILSLISY VSLKKENIFT TPKYASPGAP RMYMFHAGFR 60
SQFALKFLDP SFVPITNSLT QELQEKPSKW KFNRTAFLHQ RQEILQHVDV IKNFSLTKNS 120
VRIGQLMHYD YSSHKYVFSI SNNFRSLLPD VSPIMNKHYN ICAVVGNSGI LTGSQCGQEI 180
DKSDFVFRCN FAPTEAFQRD VGRKTNLTTF NPSILEKYYN NLLTIQDRNN FFLSLKKLDG 240
AILWIPAFFF HTSATVTRTL VDFFVEHRGQ LKVQLAWPGN IMQHVNRYWK NKHLSPKRLS 300
TGILMYTLAS AICEEIHLYG FWPFGFDPNT REDLPYHYYD KKGTKFTTKW QESHQLPAEF 360
QLLYRMHGEG LTKLTLSHCA 381
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0328--Glycosyltransferase
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001675--Glyco_trans_29
IPR012163--Sialyl_trans
PROSITE
Pfam

PF00777--Glyco_transf_29
Gene Ontology

GO:0000139--C:Golgi membrane
GO:0030173--C:integral component of Golgi membrane
GO:0003828--F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0033691--F:sialic acid binding
GO:0044267--P:cellular protein metabolic process
GO:0006488--P:dolichol-linked oligosaccharide biosynthetic process
GO:0001574--P:ganglioside biosynthetic process
GO:0009100--P:glycoprotein metabolic process
GO:0006688--P:glycosphingolipid biosynthetic process
GO:0006491--P:N-glycan processing
GO:0009311--P:oligosaccharide metabolic process
GO:0043687--P:post-translational protein modification
GO:0006486--P:protein glycosylation
GO:0018279--P:protein N-linked glycosylation via asparagine
GO:0097503--P:sialylation