| Tag |
Content |
| dbPAF ID |
dbPAF-0001464 |
| Uniprot Accession |
O43172; PRP4_HUMAN; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4;
|
| Genbank Protein ID |
NP_001231855.1; NP_004688.2;
|
| Genbank Nucleotide ID |
NM_001244926.1; NM_004697.4;
|
| Protein Name |
U4/U6 small nuclear ribonucleoprotein Prp4 |
| Protein Synonyms/Alias |
PRP4 homolog;hPrp4;U4/U6 snRNP 60 kDa protein;WD splicing factor Prp4; |
| Gene Name |
PRPF4 |
| Gene Synonyms/Alias |
PRP4; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.Functional Description
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MASSRASSTQ ATKTKAPDDL VAPVVKKPHI YYGSLEEKER ERLAKGESGI LGKDGLKAGI 60
EAGNINITSG EVFEIEEHIS ERQAEVLAEF ERRKRARQIN VSTDDSEVKA CLRALGEPIT 120
LFGEGPAERR ERLRNILSVV GTDALKKTKK DDEKSKKSKE EYQQTWYHEG PNSLKVARLW 180
IANYSLPRAM KRLEEARLHK EIPETTRTSQ MQELHKSLRS LNNFCSQIGD DRPISYCHFS 240
PNSKMLATAC WSGLCKLWSV PDCNLLHTLR GHNTNVGAIV FHPKSTVSLD PKDVNLASCA 300
ADGSVKLWSL DSDEPVADIE GHTVRVARVM WHPSGRFLGT TCYDRSWRLW DLEAQEEILH 360
QEGHSMGVYD IAFHQDGSLA GTGGLDAFGR VWDLRTGRCI MFLEGHLKEI YGINFSPNGY 420
HIATGSGDNT CKVWDLRQRR CVYTIPAHQN LVTGVKFEPI HGNFLLTGAY DNTAKIWTHP 480
GWSPLKTLAG HEGKVMGLDI SSDGQLIATC SYDRTFKLWM AE
523Fasta Sequence
>O43172|PRPF4|Homo sapiens(Human)
MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0682--Retinitis pigmentosa
KW-0747--Spliceosome
KW-0853--WD repeat
|
| Interpro |
IPR020472--G-protein_beta_WD-40_rep
IPR027106--Prp4
IPR014906--PRP4-like
IPR003648--SFM
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
|
| PROSITE |
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
|
| Pfam |
PF08799--PRP4
PF00400--WD40
|
| Gene Ontology |
GO:0015030--C:Cajal body
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0097525--C:spliceosomal snRNP complex
GO:0071001--C:U4/U6 snRNP
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0030621--F:U4 snRNA binding
GO:0017070--F:U6 snRNA binding
GO:0010467--P:gene expression
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006396--P:RNA processing
GO:0008380--P:RNA splicing
GO:0000375--P:RNA splicing, via transesterification reactions
|
