dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001461
Uniprot Accession O43166; SI1L1_HUMAN; J3KP19; O95321; Q9UDU4; Q9UNU4;
Genbank Protein ID NP_001271174.1; NP_001271175.1; NP_001271176.1; NP_056371.1; XP_005267573.1; XP_005267576.1; XP_006720172.1; XP_006720175.1; XP_011534932.1; XP_011534933.1; XP_011534934.1; XP_011534935.1; XP_011534936.1; XP_011534937.1;
Genbank Nucleotide ID NM_001284245.1; NM_001284246.1; NM_001284247.1; NM_015556.2; XM_005267516.3; XM_005267519.1; XM_006720109.2; XM_006720112.1; XM_011536630.1; XM_011536631.1; XM_011536632.1; XM_011536633.1; XM_011536634.1; XM_011536635.1;
Protein Name Signal-induced proliferation-associated 1-like protein 1
Protein Synonyms/Alias
Gene Name SIPA1L1
Gene Synonyms/Alias E6TP1;KIAA0440;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 178 (View all)
PositionPeptidesSourceReferences ( PMIDs )
9TSLKRSQTERPLATDPhosphoSitePlus22135298
31DGTPKVHTDDFYMRRPhosphoSitePlus22135298
35KVHTDDFYMRRFRSQPhosphoSitePlus22135298
68GSHHITSTPGVPKMGPhosphoSitePlus;curated22135298; 23186163
94KENIKESSRSSQEIEcurated25849741
96NIKESSRSSQEIETScurated25849741
97IKESSRSSQEIETSScurated25849741; 24961811
113LDSLSSKSSPVSQGScurated25627689; 23090842
114DSLSSKSSPVSQGSScurated25627689
120SSPVSQGSSVSLNSNcurated23090842
123VSQGSSVSLNSNDSAcurated23090842
126GSSVSLNSNDSAMLKcurated23090842
129VSLNSNDSAMLKSIQPhosphoSitePlus22135298
161LMPEAYPSSPRKALRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18220336; 16381945; 23193290; 19664995; 18988627; 19060867;
162MPEAYPSSPRKALRRdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 19276368; 19664995; 18988627;
174LRRIRQRSNSDITISdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
176RIRQRSNSDITISELdbPTM 3.0;PhosphoSitePlus;curated20736484; 21659604; 16381945; 23193290; 22135298; 22817900;
179QRSNSDITISELDVDPhosphoSitePlus22135298
187ISELDVDSFDECISPPhosphoSitePlus;UniProt;curated22135298; 24275569; 26074081
193DSFDECISPTYKTGPPhosphoSitePlus;UniProt;curated22135298; 24275569; 26074081
Sequence
(Fasta)		MTSLKRSQTE RPLATDRASV VGTDGTPKVH TDDFYMRRFR SQNGSLGSSV MAPVGPPRSE 60
GSHHITSTPG VPKMGVRARI ADWPPRKENI KESSRSSQEI ETSSCLDSLS SKSSPVSQGS 120
SVSLNSNDSA MLKSIQNTLK NKTRPSENMD SRFLMPEAYP SSPRKALRRI RQRSNSDITI 180
SELDVDSFDE CISPTYKTGP SLHREYGSTS SIDKQGTSGE SFFDLLKGYK DDKSDRGPTP 240
TKLSDFLITG GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR 300
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR HNVIKRRNTT 360
TGASAAAVAS LVSGPLSHSA SFSSPMGSTE DLNSKGSLSM DQGDDKSNEL VMSCPYFRNE 420
IGGEGERKIS LSKSNSGSFS GCESASFEST LSSHCTNAGV AVLEVPKENL VLHLDRVKRY 480
IVEHVDLGAY YYRKFFYQKE HWNYFGADEN LGPVAVSIRR EKPDEMKENG SPYNYRIIFR 540
TSELMTLRGS VLEDAIPSTA KHSTARGLPL KEVLEHVVPE LNVQCLRLAF NTPKVTEQLM 600
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN NESAGPAFEE FLQLLGERVR LKGFEKYRAQ 660
LDTKTDSTGT HSLYTTYKDY EIMFHVSTML PYTPNNKQQL LRKRHIGNDI VTIVFQEPGA 720
QPFSPKNIRS HFQHVFVIVR VHNPCSDSVC YSVAVTRSRD VPSFGPPIPK GVTFPKSNVF 780
RDFLLAKVIN AENAAHKSEK FRAMATRTRQ EYLKDLAEKN VTNTPIDPSG KFPFISLASK 840
KKEKSKPYPG AELSSMGAIV WAVRAEDYNK AMELDCLLGI SNEFIVLIEQ ETKSVVFNCS 900
CRDVIGWTST DTSLKIFYER GECVSVGSFI NIEEIKEIVK RLQFVSKGCE SVEMTLRRNG 960
LGQLGFHVNY EGIVADVEPY GYAWQAGLRQ GSRLVEICKV AVATLSHEQM IDLLRTSVTV 1020
KVVIIPPHDD CTPRRSCSET YRMPVMEYKM NEGVSYEFKF PFRNNNKWQR NASKGPHSPQ 1080
VPSQVQSPMT SRLNAGKGDG KMPPPERAAN IPRSISSDGR PLERRLSPGS DIYVTVSSMA 1140
LARSQCRNSP SNLSSSSDTG SVGGTYRQKS MPEGFGVSRR SPASIDRQNT QSDIGGSGKS 1200
TPSWQRSEDS IADQMAYSYR GPQDFNSFVL EQHEYTEPTC HLPAVSKVLP AFRESPSGRL 1260
MRQDPVVHLS PNKQGHSDSH YSSHSSSNTL SSNASSAHSD EKWYDGDRTE SELNSYNYLQ 1320
GTSADSGIDT TSYGPSHGST ASLGAATSSP RSGPGKEKVA PLWHSSSEVI SMADRTLETE 1380
SHGLDRKTES SLSLDIHSKS QAGSTPLTRE NSTFSINDAA SHTSTMSSRH SASPVVFTSA 1440
RSSPKEELHP AAPSQLAPSF SSSSSSSSGP RSFYPRQGAT SKYLIGWKKP EGTINSVGFM 1500
DTRKRHQSDG NEIAHTRLRA STRDLRASPK PTSKSTIEED LKKLIDLESP TPESQKSFKF 1560
HALSSPQSPF PSTPTSRRAL HRTLSDESIY NSQREHFFTS RASLLDQALP NDVLFSSTYP 1620
SLPKSLPLRR PSYTLGMKSL HGEFSASDSS LTDIQETRRQ PMPDPGLMPL PDTAADLDWS 1680
NLVDAAKAYE VQRASFFAAS DENHRPLSAA SNSDQLEDQA LAQMKPYSSS KDSSPTLASK 1740
VDQLEGMLKM LREDLKKEKE DKAHLQAEVQ HLREDNLRLQ EESQNASDKL KKFTEWVFNT 1800
IDMS 1805
Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0343--GTPase activation
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0771--Synaptosome
KW-0832--Ubl conjugation
Interpro

IPR001478--PDZ
IPR000331--Rap_GAP_dom
IPR030770--SIPA1L1
IPR021818--SIPA1L_C
PROSITE

PS50106--PDZ
PS50085--RAPGAP
Pfam

PF02145--Rap_GAP
PF11881--SPAR_C
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0043197--C:dendritic spine
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0005096--F:GTPase activator activity
GO:0031532--P:actin cytoskeleton reorganization
GO:0090630--P:activation of GTPase activity
GO:0048013--P:ephrin receptor signaling pathway
GO:0050770--P:regulation of axonogenesis
GO:0061001--P:regulation of dendritic spine morphogenesis
GO:0043087--P:regulation of GTPase activity
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0048167--P:regulation of synaptic plasticity