dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001460
Uniprot Accession O43164; PJA2_HUMAN; A8K6U4; D3DSZ5; Q68D49; Q8N1G5;
Genbank Protein ID NP_055634.3;
Genbank Nucleotide ID NM_014819.4;
Protein Name E3 ubiquitin-protein ligase Praja-2
Protein Synonyms/Alias
Gene Name PJA2
Gene Synonyms/Alias KIAA0438;RNF131;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
Phosphorylation Sites
 dbPAF PTMs: 49 (View all)
PositionPeptidesSourceReferences ( PMIDs )
4----MSQYTEKEPAAdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 23186163
28WPKPAGGYQTITGRRPhosphoSitePlus;curated22135298; 22817900
30KPAGGYQTITGRRYGPhosphoSitePlus22135298
42RYGRRHAYVSFKPCMPhosphoSitePlus;curated22135298; 22817900
44GRRHAYVSFKPCMTRPhosphoSitePlus22135298
63LGRAGDDYEVLELDDdbPTM 3.0;PhosphoSitePlus;curated20007894; 20562096; 16381945; 23193290; 22135298; 22817900
76DDVPKENSSGSSPLDPhosphoSitePlus;curated22135298; 25627689; 23186163
77DVPKENSSGSSPLDQcurated25627689
79PKENSSGSSPLDQVDdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 25627689
80KENSSGSSPLDQVDScurated25627689; 22199227; 20068231
88PLDQVDSSLPSEPIFcurated25627689
134EGRDTLGSSTNLHNHPhosphoSitePlus22135298
167IALVHTDSYDPDGKHPhosphoSitePlus22135298
168ALVHTDSYDPDGKHGPhosphoSitePlus22135298
193EVVEGSRYQESLGNTPhosphoSitePlus;curated22135298; 20873877
196EGSRYQESLGNTVFEPhosphoSitePlus;curated22135298; 23917254; 20873877; 23663014; 26074081
212ENREAEAYTGLSPPVPhosphoSitePlus;curated22135298; 22817900
216AEAYTGLSPPVPSFNPhosphoSitePlus;curated22135298; 25627689; 26074081
235DEFEELDSVPLVKSSdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19664994; 16381945; 23193290; 18988627; 22135298; 22817900
241DSVPLVKSSAGDTEFcurated25627689
Sequence
(Fasta)		MSQYTEKEPA AMDQESGKAV WPKPAGGYQT ITGRRYGRRH AYVSFKPCMT RHERSLGRAG 60
DDYEVLELDD VPKENSSGSS PLDQVDSSLP SEPIFEKSET EIPTCGSALN QTTESSQSFV 120
AVHHSEEGRD TLGSSTNLHN HSEGEYIPGA CSASSVQNGI ALVHTDSYDP DGKHGEDNDH 180
LQLSAEVVEG SRYQESLGNT VFELENREAE AYTGLSPPVP SFNCEVRDEF EELDSVPLVK 240
SSAGDTEFVH QNSQEIQRSS QDEMVSTKQQ NNTSQERQTE HSPEDAACGP GHICSEQNTN 300
DREKNHGSSP EQVVRPKVRK LISSSQVDQE TGFNRHEAKQ RSVQRWREAL EVEESGSDDL 360
LIKCEEYDGE HDCMFLDPPY SRVITQRETE NNQMTSESGA TAGRQEVDNT FWNGCGDYYQ 420
LYDKDEDSSE CSDGEWSASL PHRFSGTEKD QSSSDESWET LPGKDENEPE LQSDSSGPEE 480
ENQELSLQEG EQTSLEEGEI PWLQYNEVNE SSSDEGNEPA NEFAQPAFML DGNNNLEDDS 540
SVSEDLDVDW SLFDGFADGL GVAEAISYVD PQFLTYMALE ERLAQAMETA LAHLESLAVD 600
VEVANPPASK ESIDGLPETL VLEDHTAIGQ EQCCPICCSE YIKDDIATEL PCHHFFHKPC 660
VSIWLQKSGT CPVCRRHFPP AVIEASAAPS SEPDPDAPPS NDSIAEAP 709
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0436--Ligase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR030639--Praja-2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0045111--C:intermediate filament cytoskeleton
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0016874--F:ligase activity
GO:0034236--F:protein kinase A catalytic subunit binding
GO:0034237--F:protein kinase A regulatory subunit binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0035329--P:hippo signaling
GO:0007616--P:long-term memory
GO:0016567--P:protein ubiquitination
GO:0010738--P:regulation of protein kinase A signaling