dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001458
Uniprot Accession O43157; PLXB1_HUMAN; A6H8Y2; Q6NY20; Q9UIV7; Q9UJ92; Q9UJ93;
Genbank Protein ID NP_001123554.1; NP_002664.2;
Genbank Nucleotide ID NM_001130082.2; NM_002673.5;
Protein Name Plexin-B1
Protein Synonyms/Alias Semaphorin receptor SEP;
Gene Name PLXNB1
Gene Synonyms/Alias KIAA0407;PLXN5;SEP;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
674DAGPMVASHQSPLVSPhosphoSitePlus22135298
677PMVASHQSPLVSPDPPhosphoSitePlus22135298
691PPARGGPSPSPPTAPPhosphoSitePlus22135298
693ARGGPSPSPPTAPKAPhosphoSitePlus;curated22135298; 23403867; 24667141
696GPSPSPPTAPKALATPhosphoSitePlus22135298
1107QDVLGMVTVAGVPCAcurated26074081
1535QLENLESSVRDRCKKPhosphoSitePlus22135298
1612QLSNLLNSKLFLTKFPhosphoSitePlus22135298
1667LSDLVAQYVAKNPKLPhosphoSitePlus22135298
1708DSVGEPLYMLFRGIKdbPTM 3.0;PhosphoSitePlus;curated19805522; 16381945; 23193290; 22135298; 22817900
1727KGPVDSVTGKAKYTLcurated23911959
1732SVTGKAKYTLNDNRLdbPTM 3.0;PhosphoSitePlus;curated19805522; 16381945; 23193290; 22135298; 22817900
1870DYVPGERTPMLEDVDPhosphoSitePlus22135298
1902PPRPRRGSLRGGEREdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
1928RLLSMKGTLQKFVDDPhosphoSitePlus22135298
Sequence
(Fasta)		MPALGPALLQ ALWAGWVLTL QPLPPTAFTP NGTYLQHLAR DPTSGTLYLG ATNFLFQLSP 60
GLQLEATVST GPVLDSRDCL PPVMPDECPQ AQPTNNPNQL LLVSPGALVV CGSVHQGVCE 120
QRRLGQLEQL LLRPERPGDT QYVAANDPAV STVGLVAQGL AGEPLLFVGR GYTSRGVGGG 180
IPPITTRALW PPDPQAAFSY EETAKLAVGR LSEYSHHFVS AFARGASAYF LFLRRDLQAQ 240
SRAFRAYVSR VCLRDQHYYS YVELPLACEG GRYGLIQAAA VATSREVAHG EVLFAAFSSA 300
APPTVGRPPS AAAGASGASA LCAFPLDEVD RLANRTRDAC YTREGRAEDG TEVAYIEYDV 360
NSDCAQLPVD TLDAYPCGSD HTPSPMASRV PLEATPILEW PGIQLTAVAV TMEDGHTIAF 420
LGDSQGQLHR VYLGPGSDGH PYSTQSIQQG SAVSRDLTFD GTFEHLYVMT QSTLLKVPVA 480
SCAQHLDCAS CLAHRDPYCG WCVLLGRCSR RSECSRGQGP EQWLWSFQPE LGCLQVAAMS 540
PANISREETR EVFLSVPDLP PLWPGESYSC HFGEHQSPAL LTGSGVMCPS PDPSEAPVLP 600
RGADYVSVSV ELRFGAVVIA KTSLSFYDCV AVTELRPSAQ CQACVSSRWG CNWCVWQHLC 660
THKASCDAGP MVASHQSPLV SPDPPARGGP SPSPPTAPKA LATPAPDTLP VEPGAPSTAT 720
ASDISPGASP SLLSPWGPWA GSGSISSPGS TGSPLHEEPS PPSPQNGPGT AVPAPTDFRP 780
SATPEDLLAS PLSPSEVAAV PPADPGPEAL HPTVPLDLPP ATVPATTFPG AMGSVKPALD 840
WLTREGGELP EADEWTGGDA PAFSTSTLLS GDGDSAELEG PPAPLILPSS LDYQYDTPGL 900
WELEEATLGA SSCPCVESVQ GSTLMPVHVE REIRLLGRNL HLFQDGPGDN ECVMELEGLE 960
VVVEARVECE PPPDTQCHVT CQQHQLSYEA LQPELRVGLF LRRAGRLRVD SAEGLHVVLY 1020
DCSVGHGDCS RCQTAMPQYG CVWCEGERPR CVTREACGEA EAVATQCPAP LIHSVEPLTG 1080
PVDGGTRVTI RGSNLGQHVQ DVLGMVTVAG VPCAVDAQEY EVSSSLVCIT GASGEEVAGA 1140
TAVEVPGRGR GVSEHDFAYQ DPKVHSIFPA RGPRAGGTRL TLNGSKLLTG RLEDIRVVVG 1200
DQPCHLLPEQ QSEQLRCETS PRPTPATLPV AVWFGATERR LQRGQFKYTL DPNITSAGPT 1260
KSFLSGGREI CVRGQNLDVV QTPRIRVTVV SRMLQPSQGL GRRRRVVPET ACSLGPSCSS 1320
QQFEEPCHVN SSQLITCRTP ALPGLPEDPW VRVEFILDNL VFDFATLNPT PFSYEADPTL 1380
QPLNPEDPTM PFRHKPGSVF SVEGENLDLA MSKEEVVAMI GDGPCVVKTL TRHHLYCEPP 1440
VEQPLPRHHA LREAPDSLPE FTVQMGNLRF SLGHVQYDGE SPGAFPVAAQ VGLGVGTSLL 1500
ALGVIIIVLM YRRKSKQALR DYKKVQIQLE NLESSVRDRC KKEFTDLMTE MTDLTSDLLG 1560
SGIPFLDYKV YAERIFFPGH RESPLHRDLG VPESRRPTVE QGLGQLSNLL NSKLFLTKFI 1620
HTLESQRTFS ARDRAYVASL LTVALHGKLE YFTDILRTLL SDLVAQYVAK NPKLMLRRTE 1680
TVVEKLLTNW MSICLYTFVR DSVGEPLYML FRGIKHQVDK GPVDSVTGKA KYTLNDNRLL 1740
REDVEYRPLT LNALLAVGPG AGEAQGVPVK VLDCDTISQA KEKMLDQLYK GVPLTQRPDP 1800
RTLDVEWRSG VAGHLILSDE DVTSEVQGLW RRLNTLQHYK VPDGATVALV PCLTKHVLRE 1860
NQDYVPGERT PMLEDVDEGG IRPWHLVKPS DEPEPPRPRR GSLRGGERER AKAIPEIYLT 1920
RLLSMKGTLQ KFVDDLFQVI LSTSRPVPLA VKYFFDLLDE QAQQHGISDQ DTIHIWKTNS 1980
LPLRFWINII KNPQFVFDVQ TSDNMDAVLL VIAQTFMDAC TLADHKLGRD SPINKLLYAR 2040
DIPRYKRMVE RYYADIRQTV PASDQEMNSV LAELSWNYSG DLGARVALHE LYKYINKYYD 2100
QIITALEEDG TAQKMQLGYR LQQIAAAVEN KVTDL 2136
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR002909--IPT
IPR031148--Plexin
IPR016201--Plexin-like_fold
IPR013548--Plexin_cytoplasmic_RasGAP_dom
IPR002165--Plexin_repeat
IPR008936--Rho_GTPase_activation_prot
IPR001627--Semap_dom
IPR015943--WD40/YVTN_repeat-like_dom
PROSITE

PS51004--SEMA
Pfam

PF08337--Plexin_cytopl
PF01437--PSI
PF01403--Sema
PF01833--TIG
Gene Ontology

GO:0005576--C:extracellular region
GO:0005887--C:integral component of plasma membrane
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0002116--C:semaphorin receptor complex
GO:0032794--F:GTPase activating protein binding
GO:0004872--F:receptor activity
GO:0017154--F:semaphorin receptor activity
GO:0030215--F:semaphorin receptor binding
GO:0004888--F:transmembrane signaling receptor activity
GO:0048675--P:axon extension
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0035556--P:intracellular signal transduction
GO:0007162--P:negative regulation of cell adhesion
GO:0033689--P:negative regulation of osteoblast proliferation
GO:0048812--P:neuron projection morphogenesis
GO:0043931--P:ossification involved in bone maturation
GO:0050772--P:positive regulation of axonogenesis
GO:0043547--P:positive regulation of GTPase activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030334--P:regulation of cell migration
GO:0008360--P:regulation of cell shape
GO:0051493--P:regulation of cytoskeleton organization
GO:0043087--P:regulation of GTPase activity
GO:0071526--P:semaphorin-plexin signaling pathway
GO:1902287--P:semaphorin-plexin signaling pathway involved in axon guidance
GO:1900220--P:semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
GO:0007165--P:signal transduction